After 20 years of service as the executive editor of this series, I will now become emeritus. It has been an honor to work with the many distinguished and talented scientists who have significantly contributed to the scholarship and quality of each volume. This international cadre of highly professional authors and editors were a delight to work with. They were a repository of an awesome fund and diversity of knowledge, with which I was privileged to be associated. I am equally appreciative of the unflagging support of the publisher and its staff without which these volumes could not be produced. During my tenure, I have also enjoyed the support and encouragement of my wife, Joanne. She is and has always been a good counselor as well as best friend, and I wish to express my thanks.

This volume continues our objective of expanding the intellectual horizon of clinical chemistry. Included are chapters on: Clinical Applications of Cytokine Assays; Diagnosis and Treatment of Acute Pancreatitis; Mitochondrial Mutations and Mitochondrial Diseases; Pathobiochemistry of Nephrotic Syndrome; Total Antioxidant Capacity; Autoantibodies to dsDNA, Ro/SSA, and LaSSB in Systemic Lupus Erythematosis; and Lymphoid Malignancies and Immunosuppressive Analysis. The meld of analytical, anatomical, subcellular, and molecular sciences represented by these subjects will continue to evolve and expand. Clinical chemistry is a vibrant and vital profession. Future volumes, their editors, and their contributors will undoubtedly be an important part of the practice and science of clinical chemistry.

As is my custom, I would like to dedicate this volume. It is dedicated to the readership, which has been attentive and responsive over the years. It is dedicated to the future, which looks bright and challenging. Finally, it is dedicated to my son Girard, whose courage is an inspiration to me.

Herbert E. Spiegel


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