Biomaterial Manipulated Cells

Cell-based therapy may have the capacity to repopulate stroke-injured brain; however, its ability to restore structural and functional neural connections might be limited by the vast amount of brain parenchymal loss. The core of the infarct changes rapidly to a cystic cavity, and even the most capable cells might need intrinsic organization and a template to guide restructuring. To address this need, a pilot experiment was performed (50), in which a NSC-polymer complex was implanted into the infarct region of the focal ischemic area in mice. The NSC-polymer complex filled the cavity with an intricate meshwork of many highly arborized neurites of both host- and donor-derived neurons, and some anatomical connections appeared to be reconstituted, with evidence of neovascularization (50). Polyglycolic acid (PGA) is a synthetic biodegradable polymer used widely in clinical medicine (51). Highly hydrophilic, PGA loses its mechanical strength rapidly over 2 to 4 weeks in vivo. NSCs seeded onto the three-dimensional, highly porous PGA scaffolded and cotransplanted into the infarction cavity in mouse brains injured by ischemia-facilitated reformation of structural and functional circuits, particularly, if the cells had been engineered ex vivo to express factors that might attract in-growth of host fibers. New bioscaffolds might provide a matrix to guide cellular organization and growth, allow diffusion of nutrients between the transplanted cells and brain cells, become vascularized, and then disappear, obviating concerns about long-term biocompatibility.

Metabolism Masterclass

Metabolism Masterclass

Are You Sick And Tired Of All The Fat-Burning Tricks And Trends That Just Don’t Deliver? Well, Get Set To Discover The Easy, Safe, Fast, And Permanent Way To Mega-Charge Your Metabolism And Lose Excess Fat Once And For All! This Weight Blasting Method Is Easy AND Natural… And Will Give You The Hot Body And Killer Energy Levels You’ve Been Dreaming Of.

Get My Free Ebook


Post a comment