Autologous blood infusions have been used to produce experimental ICH in cats. An early experimental ICH study demonstrated an important relationship between the size and location of an intracerebral hematoma, functional deficits, and ICP elevations (45). Other findings demonstrated that increased ICP was the main cause of blood volume/flow reductions shortly after hematoma induction in the basal ganglia (46). The relationship between neurologic deficits and hematoma volume was also observed, and it was found that urokinase-induced resolution of internal capsule hematomas also improved neurologic outcome (47). These findings in cats support those in human ICH, which reported a strong relationship between hematoma size and clinical outcome (48).
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