Cell Fusion Phenomenon

Recent reports of cell fusion have raised some doubts about the existence of somatic stem cell plasticity (60). Cell fusion has been known to produce viable cells and has a major role in mammalian development and differentiation. In vitro, adult BMSCs from mice fuse with embryonic NSCs, resulting in two sets of chromosomes and mixed marker sets (61 ). Immunochemical, morphologic, and physiologic criteria for determining neuronal transdifferentiation are critical for the development of an effective cell therapy for stroke.

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