Comparisons with Other Species

The above-described rodent models were an extension of earlier experiences in larger animals, and many such models continue to be used, as recently reviewed (118). Suffice it to point out here that the technical capabilities of large animal models with respect to physiologic monitoring and control (and, more recently, access to in vivo imaging) are increasingly applicable to rodent models. Stringent standards of model control, historically more routine in large animals, are recognized to be at least as critical in rodents. The lower cost of purchasing and maintaining small animals, and, in most cases, their greater genetic homogeneity remain important advantages, but the experimental complexity of rodent studies must rival that of large animal experiments to meet rising standards in data reliability.

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