Conclusions

Overall, focal ischemia models and experimental stroke drug development work have had a great impact on our understanding of stroke and on development of novel therapies during the last 2 decades, but results from experimental work must be interpreted with caution. Experimental and clinical studies have developed interactively regarding the various demands, design, time window, and outcome measures, and those in the field have attempted to establish uniform standards (7,153,154). The very recent advancement in clinical stroke care and research is the development of diffusion- and perfusion-weighted MRI in experimental models and the recent utilization of this superb technology to clinical practice and trials.

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