The comparative effectiveness of magnesium, diazepam, magnesium + diazepam, and placebo in patients awakening from CPR from out-of-hospital CA was studied in 2002 (28). The study agents were administered intravenously upon ROSC at the following doses: 2 g magnesium, 10 mg diazepam, 2 g magnesium+10 mg diazepam, and placebo. At three months, no significant difference was noted in the proportion of patients who awoke (magnesium: 46.7%, diazepam: 30.7%, magnesium + diazepam: 29.3%, and placebo: 37.3%). The mortality at three months was likewise similar in the four groups: magnesium: 62.7%, diazepam: 76.0%, magnesium+diazepam: 77.3%, and placebo: 68% (28).

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