Glucocorticoids

The BRCT 1 trial allowed for the addition of glucocorticoids to the study agent (thiopental or placebo) at the discretion of the treating physician. This arm of the BRCT 1 was not controlled, and the data was analyzed retrospectively (19). The inclusion criteria and the primary outcome measure were identical to the thiopental study. The choice of glucocorticoid, either dexametha-zone or methylprednisolone, was dependent on the treatment preference of the center and was administered during the first 8 hours post ROSC. The glucocorticoid treatment doses were divided into no dose, low dose (1-20 mg of dexamethazone), medium dose (21-70 mg of dex-amathazone), and high dose (equivalent >70 mg of dexamathazone). The percentage of patients with good outcome (CPC 1 and 2) was similar for all dose groups, which ranged from 34.0% to 37.3% ( 19 ).

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