A small but real risk of groin complications exists for patients who undergo an angiogram. The risk increases slightly with prolonged sheath placement, use of closure devices, and anticoagulation, with the main risk being hemorrhage and vessel damage. Significant hematocrit shifts might indicate a retroperitoneal hemorrhage, and significant compartmentalization into the muscles of the thigh might occur, without external detection. Contained hematomas in the groin are uncomfortable for the patient but not life threatening. Pseudoaneurysm in the groin vessels can occur as a late complication secondary to large local hematoma.

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