Info

Drug-specific

Drug

action

of action

action

Dosage

adverse effects

Diazoxide

Activates adenosine triphosphate-sensitive potassium channels

1-5 min

1-12 hr

IV bolus: 50-100 mg q 10 min; continuous infusion: 15-30 mg/min

Severe hyperglycemia, salt and water retention

Hydralazine

Nitric oxide interferes with calcium mobilization in smooth muscle

15-30 min

3-4 hr

2.5-10 mg IV bolus (up to 40 mg)

Drug-induced lupus syndrome, serum-sicknesslike illness

Sodium nitro-

Nitric oxide

Immediate

2-3 min

0.25-10 |jg/kg/min IV

Cyanide toxicity

prusside

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