Intracerebral Blood Infusion Ich Models

Intraparenchymal infusion (or injection) of autologous blood is the classic technique by which to create an intracerebral hematoma. Clearly, this method does not reproduce the bleeding event of spontaneous ICH in humans, i.e., arterial vessel rupture. However, this model does enable the infused blood volume to be controlled and, therefore, generates reasonably reproducible hematoma sizes and mass effects. These models have been very useful for studying the pathophysiologic and biochemical events that result from the presence of blood in the brain tissue. Disadvantages of blood infusion models are the potential for ventricular rupture and for backflow of the infused blood along the needle track (24,25). Such events during blood infusion can lead to intraventricular and/or subarachnoid leakage of blood. This problem was addressed by a double hemorrhage method, in which a small volume of blood is initially infused into the caudate at a slow rate, followed by a 7-min pause to allow the blood to clot along the needle track, and then infusion of the remaining blood to produce a hematoma (24). The clotting of blood around the shaft of the needle prevents the backflow of blood into the subarachnoid space during the subsequent infusion, thereby enhancing the production of reproducible hematoma volumes. This double-infusion approach has been employed by several groups (3,26).

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