Lidoflazine

As a follow-up study, the BRCT 2 compared the functional outcomes of patients treated with the calcium channel blocker lidoflazine (1 mg/kg IV) within 30 minutes after ROSC, followed by 0.25 mg/kg at 8 hours and 16 hours (n = 257) or placebo (20). The 6-month functional outcome by CPC showed no significant difference between groups, with good outcome in 15% of lidoflazine-treated patients, compared to 13% in the placebo-treated patients. The 6-month mortality was also similar, at 82% with lidoflazine treatment and 83% with placebo (20 ).

Despite the failure of the BRCT trials to show therapeutic benefit, many important findings were noted, especially pertaining to epidemiology and methodology of clinical trials in brain injury after CA. After the BRCT 1 trials, the American Heart Association and the European Resuscitation Council jointly sponsored a consensus meeting to facilitate research and reduce variability in methodologies. The task force published the "Utstein Style Guidelines" in 1991, which provided recommendations for the conducting, reporting, and reviewing of research on out-of-hospital CA (21); in 1997, they published guidelines for in-hospital resuscitation (22). Many of these methodologies were used in succeeding trials, especially in the HACA hypothermia trial in 2002 (8 ).

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