Hematomas were generated in the caudate nucleus of vervet monkeys by allowing femoral arterial blood to enter the structure via a stereotactically implanted needle (61). ICP peaked at 51 ± 8 mmHg at 3 min after the bleed and remained high throughout the 3 hr procedure. rCBF was significantly reduced in all brain regions for 1 hr after the ictus, with the lowest values in the periphery of the hematoma. Some rCBF values were below the ischemic threshold for 90 min after the hemorrhage. Another group (62) reported an early thrombolytic treatment study in Macaque monkeys in abstract form in 1982. They found that urokinase promoted basal ganglia hematoma resorption that correlated with improvement in the clinical exam.
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