Outcome Measures

Outcome measures should include both functional response and infarct volume (7). Infarct volume can easily and objectively be measured post mortem with a number of histologic techniques or in vivo by imaging. Early lesion development can be monitored with MRI techniques, such as diffusion- and perfusion-weighted MRI (133,134), and compared to final infarct volumes measured histologically at time points after induction of ischemia. Long-term experiments are necessary because some drugs might simply delay the maturation of ischemic injury and deliver encouraging results in acute experiments, but the benefit might be lost at later time points (135,136).

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