Reactive Oxygen Species And Superoxide Dismutases

Administration of exogenous superoxide dismutase (SOD) during focal ischemic preconditioning abolishes tolerance induction (71), suggesting that induction of ischemic tolerance is triggered by the generation of ROS during preconditioning. However, the role of endogenous antioxidant mechanisms in the induction of tolerance is not clear. Manganese SOD (MnSOD) expression and activity are increased in vivo after preconditioning with LPS (72), hyper-baric oxygenation (64) and ischemia (73), and hypoxic preconditioning in cultured neurons (74). In contrast, no differences in expression or activity of either MnSOD or copper-zinc SOD (CuZnSOD) were observed in rats in connection with tolerance induction by spreading depression (75) or focal ischemia (76 ).

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