The Ischemic Penumbra

The ischemic penumbra can be thought of as brain tissue in which the cerebral blood flow (CBF) is reduced to the point at which electrical failure occurs but is still above the point of energy failure and ion-pump failure (1). Theoretically, this underperfused tissue can be salvaged from infarction. A number of physiologic and metabolic variables that affect the ability to save this tissue from infarction have been identified, and medical therapies to manipulate them are discussed below.

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