YM-872 (Yamanouchi Pharmaceutical Co.) is an a-amino-3-(3-hydroxy-5-methylisoxazole-4-yl)-propanoic acid antagonist. A dose-finding trial with this agent was completed without any safety concerns. A Phase 2 trial has been completed, in which patients were randomized to a 24-hr IV infusion of YM-872 or placebo within 6 hr of symptom onset. Patients with brain stem or cerebellar infarcts were excluded. Magnetic resonance imaging, including diffusion-weighted imaging and perfusion-weighted imaging, was performed prior to the randomization of each patient and again after 1 month. Although no significant safety concerns were noted, no significant treatment benefits were detected (Company press release, Yamanouchi Pharmaceutical).
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