Cardiogenic Brain Embolism

Stroke admission rates have been observed to be high among heavy drinkers 10 , Some studies also suggest that alcohol abuse may associate with ischemic stroke recurrence 11,12 . A study on recent alcohol intake showed that heavy drinking is an independent risk factor for most subtypes of ischemic stroke and particularly a risk factor for cardiogenic brain embolism 13 . Table 7.1 Previously published and new case histories illustrating several different mechanisms that could link alcohol abuse...

Preface

With advances in molecular biology, the degree to which genetic makeup predetermines susceptibility to alcohol abuse and alcoholism is being defined. With more powerful tools for data collection and analysis and increased funding in this area, the epidemiology of alcohol consumption and alcohol-related health issues is being better elucidated. With the blossoming of the field of neuroscience, neural mechanisms underlying alcohol addiction and appetitive...

Ethanol And Other Aspects Of Hemostasis

Because a variety ofhemostatic factors beyond those associated with platelets also contribute to the complications associated with coronary heart disease, it is important to consider the above information on platelets in the context of some of these other observations. One of the strongest risk factors for myocardial infarction is elevated plasma fibrinogen level 41 . The association of fibrinogen and alcohol consumption was evaluated by Mennen and colleagues 42 , Alcohol consumption was...

Alcoholism In Women And Incidence Of Ahmd

Compared to men, women drink less and experience less alcohol-related medical problems 6 , However, one third of all alcoholics in the United States are women 6 , Over the last two decades, there is no evidence of any major increase in total alcohol consumption by women, however there has been an important change in the drinking patterns and prevalence of alcohol usage among women 7 , With regard to drinking patterns, younger women report frequent heavy drinking and frequent bouts of...

Exposure To Ethanol

The cellular mechanisms by which moderate alcohol exposure directly protects, or preconditions, cardiac myocytes from ischemia-reperfusion injury are unknown. However, substantial experimental evidence suggests that an intracellular signal transduction pathway common to several important forms of cardiac preconditioning involves activation of protein kinase C 13 . Ischemic preconditioning, a protective mechanism induced when the heart is exposed to brief sublethal episodes of ischemia, is the...

Contents

1 Alcohol and cardiovascular disease large population studies YOULIAN LIAO, DANIEL McGEE AND RICHARD COOPER 1 2 The alcoholic cardiomyopathies genuine and pseudo 3 Wine and lifestyle role in cardiovascular disease and premature death S. GOYA WANNAMETHEE AND A. GERALD SHAPER 21 4 Effects ofgender on alcohol's heart dysfunction 5 Alcohol and cardiac medications interactions SIMON K.K. CHEUNG AND TIMOTHY J. REGAN 48 6 Alcohol abuse and hemorrhagic stroke 7 Alcohol abuse and ischemic stroke 8...

Alcohol and nonfatal myocardial infarction or incidence of CHD

Data on the incidence of myocardial infarction or CHD were available for about 40 of the cited cohorts. It is no longer disputed that drinkers as a group have a lower incidence of Table 1.1 Large population studies examining alcohol intake and cardiovascular disease Sample Categories of CHD Size Alcohol Intake 8 Honolulu Heart 1965-68 Program 10 Puerto Rico Heart Health Program 11 Yugoslavia Cardiovascular Disease Study Residents aged 29-62 years in Framingham, MA at exam 2 At exam 2 or exam 7...

Apolipoprotein B

Apolipoprotein B is the major structural protein for triglyceride-rich particles including chylomicrons and very low density lipoprotein (VLDL) as well as intermediate density lipoproteins (IDL) and low density lipoproteins (LDL). VLDL is sequentially metabolized to IDL and LDL by hydrolysis of the triglycerides. There are two forms of apolipoprotein B, apolipoprotein B100 and apolipoprotein B48. Apolipoprotein B48 derives from mRNA editing of apolipoprotein B100 mRNA. In the intestine, where...

Conclusions

In conclusion, a broad array of circumstantial evidence now suggests that platelet inhibitory effects of alcohol might contribute to the reduced risk of CHD mortality among moderate drinkers. This evidence includes epidemiological data, in vitro data on effects of alcohol on platelets, and studies on ex vivo platelet function after alcohol consumption in animal models and human volunteers. While the effects of multiple components of alcoholic beverages might contribute, it is likely that...

The Role Of Lifestyle

It has been suggested that differences in findings regarding specific types of drinks, and in particular the low risk seen in wine drinkers compared to other drinkers, may be due to differences in patterns of drinking and to differences in risk traits between those choosing different beverages 11 . The Kaiser Permanente Study observed wine drinkers to have the most favourable coronary risk traits and liquor (spirit) drinkers to have the least favourable traits. Interestingly, the beneficial...

Alcoholic versus viral or idiopathic chronic dilated cardiomyopathy DCM

The most prevalent confusion with the alcoholic heart disease caused by thiamine and nutritional deficiency is with viral or idiopathic chronic DCM. Between 20 and 35 of all cases ofDCM are thought to occur because of excessive ethanol intake 25 , However, in both alcoholic and idiopathic chronic DCM, the clinical picture is similar. In the early stages of both categories of congestive heart failure, the patients often show some response to bedrest, salt restriction, diuretics, and digitalis....

Alcoholic Liver Disease Role Of Free Radicals

A substantial body of evidence exists to support the contention that ROS generated during ethanol metabolism may be involved in the pathogenesis of alcoholic liver disease ALD . Decades ago, it was already emphasized by Lieber that the induction of cytochrome P450 is a critical event with respect to the development of ALD 85 , If free radical production and lipid peroxidation play a role in the development of ALD, depletion of dietary antioxidants such as vitamin E or an increase in oxidants...