Synthetic GCs are cortisone-based molecules that have undergone structural modifications designed to enhance their potencies and prolong their durations of action. Antiinflammatory GCs have a 17-hydroxyl group and methyl groups at carbons 18 and 19. Further modifications to the basic steroid structure have increased the anti-inflammatory while decreasing mineralocorticoid effects; however, it has not been possible to separate the unwanted metabolic effects while retaining the desired anti-inflammatory properties of the synthetic GCs that are systemically administered.
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Metabolism. There isn’t perhaps a more frequently used word in the weight loss (and weight gain) vocabulary than this. Indeed, it’s not uncommon to overhear people talking about their struggles or triumphs over the holiday bulge or love handles in terms of whether their metabolism is working, or not.