Coclusion Of Allergic Diseases

Asthma Free Forever

Asthma Free Forever By Jerry Ericson

Get Instant Access

Both nedocromil sodium and cromolyn sodium are useful anti-inflammatory drugs in the therapy of allergic diseases. These diseases include asthma, allergic rhinitis, and allergic ocular disorders. Additional therapeutic uses have been proposed. Nedocromil and cromolyn are both available in the United States for asthma therapy, but only cromolyn is available for the treatment of the other conditions.

Recent publications in the evidence-based literature have upheld the safety profile of the chromones, but increasingly suggest that other topical anti-inflammatory agents (e.g., glucocorticosteroids or ocular antihistamine preparations) are more effective and have comparable safety at recommended doses. Cromolyn appears to be more effective when combined with a ß-agonist. There are no data to support that addition of chromones to inhaled corticosteroids enhances efficacy. Whether other drugs can be utilized with cromolyn or nedocromil to achieve greater effectiveness and comparable safety remains to be seen. Refinements of existing formulations may also achieve greater efficacy. At present, cromolyn and nedocromil appear to be niche drugs that can be of great clinical importance for some patients.

SUGGESTED READING

Adams RJ, Fuhlbrigge A, Finkelstein JA, et al. Impact of inhaled anti-inflammatory therapy on hospitalization and emergency department visits for children with asthma. Pediatrics 2001;107:706-11. Ahluwalia P, McGill JI, Church MK. Nedocromil sodium inhibits histamine-induced itch and flare in human skin. Br J Pharmacol 2001;132:613-616. Barnes PJ, Holgate ST, Laitinen LA, Pauwels R. Asthma mechanisms, determinants of severity and treatment: the role of nedocromil sodium. Clin Exp Allergy 1995;25:771-787. Businco L, Meglio P, Amato G, et al. Evaluation of the efficacy of oral cromolyn sodium or an oligoantigenic diet in children with atopic dermatitis: a multicenter study of 1085 patients. J Invest Allergol Clin Immunol 1996;6:103-109. Childhood Asthma Management Program Research Group. Long-term effects of budesonide or nedocromil in children with asthma. N Engl J Med 2000;343:1054-1063. Crimi N, Palermo F, Oliveri R, Palermo B, Polosa R, Mistretta A. Protection of nedocromil sodium on bronchoconstriction induced by inhaled neurokinin A (NKA) in asthmatic patients. Clin Exp Allergy 1992;22:75-81.

Crossman DC, Dashwood MR, Taylor GW, Wellings R, Fuller RW. Sodium cromoglycate: evidence of tachykinin antagonist activity in the human skin. J Appl Physiol 1993;75:167-172. Donahue JG, Weiss ST, Livingston JM, Goetsch MA, Greineder DK, Platt R. Inhaled steroids and the risk of hospitalization for asthma. JAMA 1997;277:887-891. Edwards A, Holgate S, Howell J, et al. Sodium cromoglycate in childhood asthma [letter]. Thorax 2001;56:331-332.

Edwards AM. Sodium cromoglycate (Intal®) as an anti-inflammatory agent for the treatment of chronic asthma. Clin Exp Allergy 1994;24:612-623. Edwards AM, Howell JBL. The chromones: history, chemistry and clinical development. A tribute to the work of Dr. REC Altounyan. Clin Exp Allergy 2000;30:756-774. Furusho K, Nishikawa K, Sasaki S, Akasaka T, Arita M, Edwards A. The combination of nebulized sodium cromoglycate and salbutamol in the treatment of moderate-to-severe asthma in children. Pediatr Allergy Immunol 2002;13:209-216. Heinke S, Szucs G, Norris A, Droogmans G, Nilius B. Inhibition of volume-activated chloride currents in endothelial cells by chromones. Br J Pharmacol 1995;115:1393-1398. Jackson DM. The effects of nedocromil sodium, sodium cromoglycate and codeine phosphate on citric acid-

induced cough in dogs. Br J Pharmacol 1988;93:609-612. Jackson DM, Pollard CE, Roberts SM. The effect of nedocromil sodium on the isolated rabbit vagus nerve.

Eur J Pharmacol 1992;221:175-177. Janssen LJ, Wattie J, Betti PA. Effects of cromolyn and nedocromil on ion currents in canine tracheal smooth muscle. Eur Respir J 1998;12:50-56. Javdan P, Figini M, Emanueli C, Geppetti P. Nedocromil sodium reduces allergen-induced plasma extravasation in the guinea pig nasal mucosa by inhibition of tachykinin release. Allergy 1995;50:825-829. Johnston SL. Cromolyns: treatment for the common cold? Clin Exp Allergy 1996;26:989-994. Kelly KD, Spooner CH, Rowe BH. Nedocromil sodium versus sodium cromoglycate in treatment of exercise-induced bronchoconstriction: a systematic review. Eur Respir J 2001;17:39-45.

König P. The effects of cromolyn sodium and nedocromil sodium in early asthma prevention. J Allergy Clin Immunol 2000;105:S575-S585.

König P, Grigg CF. Cromolyn sodium or nedocromil in childhood asthma: does it matter? Clin Exp Allergy 2000;30:164-171.

Korhonen K, Korppi M, Remes ST, Reijonen TM, Remes K. Lung function in school-aged asthmatic children with inhaled cromoglycate, nedocromil and corticosteroid therapy. Eur Respir J 1999;13:82-86.

Laube BL, Edwards AM, Dalby RN, Creticos PS, Norman PS. The efficacy of slow versus faster inhalation of cromolyn sodium in protecting against allergen challenge in patients with asthma. J Allergy Clin Immunol 1998;101:475-483.

Lavorini F, Fontana GA, Pantaleo T, et al. Fog-induced respiratory responses are attenuated by nedocromil sodium in humans. Am J Respir Crit Care Med 2001;163:1117-1120.

MacLeod JDA. The treatment of allergic eye disease: has sodium cromoglycate had its day? Clin Exp Allergy 1999;29:436-438.

Moore C, Ehlayel MS, Junprasert J, Sorensen RU. Topical sodium cromoglycate in the treatment of moderate-to-severe atopic dermatitis. Ann Allergy Asthma Immunol 1998;81:452-458.

National Asthma Education and Prevention Program. Expert Panel Report: Guidelines for the diagnosis and management of asthma—update on selected topics 2002. J Allergy Clin Immunol 2002;110:S141-

s219.

Nerbrink OL, Lindström M, Meurling L, Svartengren M. Inhalation and deposition of nebulized sodium cromoglycate in two different particle size distributions in children with asthma. Pediatr Pulmonol 2002;34:351-360.

Norris AA, Alton EWFW. Chloride transport and the action of sodium cromoglycate and nedocromil sodium. Clin Exp Allergy 1996;26:250-253.

Romanin C, Reinsprecht M, Pecht I, Schindler H. Immunologically activated chloride channels involved in degranulation of rat mucosal mast cells. EMBO J 1991;10:3603-3608.

Spooner CH, Spooner GR, Rowe BH. Mast-cell stabilizing agents to prevent exercise-induced bronchoconstriction. Cochrane Database Syst Rev 2005;1:00075320-100000000-01652.

Stefanini GF, Saggioro A, Alvisi V, et al. Oral cromolyn sodium in comparison with elimination diet in the irritable bowel syndrome, diarrheic type: multicenter study of 428 patients. Scand J Gastroenterol 1995;30:535-541.

Theoharides TC, Wang L, Pang X, et al. Cloning and cellular localization of the rat mast cell 78-kDa protein phosphorylated in response to the mast cell "stabilizer" cromolyn. J Pharmacol Exp Ther 2000;294:810-821.

Toppet M, Fall ABK, Ferster A, et al. Antisickling activity of sodium cromoglicate in sickle-cell disease [letter]. Lancet 2000;356:309.

van der Wouden JC, Tasche MJA, Bernsen RMD, Uijen JHJM, de Jongste JC, Ducharme FM. Inhaled sodium cromoglycate for asthma in children. Cochrane Database Syst Rev 2005;1:00075320-100000000-01544.

Verin P, Dicker ID, Mortemousque B. Nedocromil sodium eyedrops are more effective than sodium cromoglycate eyedrops for the long-term management of vernal keratoconjunctivitis. Clin Exp Allergy 1999;29:529-536.

Willis EF, Clough GF, Church MK. Investigation into the mechanisms by which nedocromil sodium, frusemide and bumetanide inhibit the histamine-induced itch and flare response in human skin in vivo. Clin Exp Allergy 2004;34:450-455.

Was this article helpful?

0 0
Dealing With Asthma Naturally

Dealing With Asthma Naturally

Do You Suffer From ASTHMA Chronic asthma is a paralyzing, suffocating and socially isolating condition that can cause anxiety that can trigger even more attacks. Before you know it you are caught in a vicious cycle Put an end to the dependence on inhalers, buying expensive prescription drugs and avoidance of allergenic situations and animals. Get control of your life again and Deal With Asthma Naturally

Get My Free Ebook


Post a comment