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Principal Studies on Gene Polymorphisms Likely Involved in Human Longevity Apolipoprotein E (APOE) polymorphism studies Reference Results and conclusions The APOEe4 allele frequency was significantly decreased in centenarians versus middle-aged controls (0.05 vs. 0.11 p < .001), while the APOEe2 allele frequency was significantly increased (0.13 versus 0.07 p < .01). The APOEe2 allele frequency was significantly higher (0.07 versus 0.04 p < .05) and the APOEe4 allele lower in centenarians...

Clinical Phenotypes in Depression and Molecular Levels

In clinical studies, major depressive disorder has had four specifiers, including melancholic feature, atypical feature, catatonic feature, and postpartum onset. In the future, we should investigate the distributions of the four specifiers of depression among patients with physical illness and discuss which biological markers could link the depressive disorder and the physical illness. 4.1. Lipid Profile Levels in Patients with Major Depression with Melancholic Feature, Atypical Feature,...

Sequence Variations of Human Kallikrein Genes

Sequence changes, including polymorphisms and mutations, are clinically important. in addition to medicolegal applications, they can also be indicators for susceptibility and prognosis for different malignancies 52 . KLK3 is the most extensively studied kallikrein in this respect. Comparison of the published mRNA sequences of KLK3 revealed infrequent and inconsistent sequence variations. Baffa et al. found no evidence of mutations in the KLK3 mRNA sequence in prostate cancer compared to matched...

Hormonal Regulation of Kallikreins

Steroid hormones, acting through their receptors, play important roles in the normal development and function of many organs. In addition, they are involved in the pathogenesis of many types of cancer 146 . Several reports confirmed that many kallikreins are under steroid hormone regulation in endocrine-related tissues and cell lines 100, 147-155 . An interesting observation is the tissue-specific pattern of hormonal regulation of several of these genes in different tissues. For example, KLK4...

Cross Talk Between Kallikreins A Possible Novel Enzymatic Cascade Pathway

Interactions between serine proteases are common, and substrates of serine proteases are usually other serine proteases that are activated from an inactive precursor 66 . The involvement of serine proteases in cascade pathways is well documented. One important example is the blood coagulation cascade. Blood clots are formed by a series of zymogen activations. In this enzymatic cascade, the activated form of one factor catalyzes the activation of the next factor. Very small amounts of the...

Klk7

MRNA and extracts from normal and cancerous ovarian tissues SQ-RT-PCR, Northern and Western blots and immunohistochemistry Unfavorable prognosis Our unpublished Overexpressed in patients with late stage disease and data Associated with shorter DFS and OS Independent indicator of poor prognosis in patients with high-grade tumors and optimal debulking success Overexpressed in ovarian cancer tissues Overexpressed in patients with late-stage disease and Associated with shorter DFS and OS...

Department of Biology Technion Israel Institute of Technology Haifa 32000 Israel

Modern Proteomic 2.3. Mass 2.4. Protein 2.6. Technology Portability, Reproducibility, and Performance Characteristics 3. Proteins, Proteomics, and 4. Accessing Biological 4.1. Invasion Interface 4.2. Laser Capture 5. Preparing and Resolving Complex 5.1. Optimizing Biological 5.2. Subfractionation of Protein 6. Standardization of Proteomic 7. Combining Modern Proteomic Technologies with Traditional Histopathology 8. Practical Clinical 8.1. Tumor Markers 8.2. Disease-Related...

The Relationships Between Lipid Profile Levels Depression and Suicide Attempts

Depressive Symptoms or Depressive Disorders Most of the data that examined depressive symptoms and lipid profile levels have been from the community studies performed in different countries by the self-related depression scales. Most of these studies were performed by psychiatrists according to specifically clinical criteria in psychiatric inpatients or outpatients or in patients admitted for general health screening. 2.1.1. Depressive Symptoms and Lipid Profile Levels in the Community...

Inflammation and Immune Response in Human Longevity

Aging is not synonymous with illness. However, aging does increase the risk for certain illnesses. Overall, elderly people have an increased rate of chronic disorders, infections, autoimmune disorders, and cancer. A significant part of this increased risk seems to be related to aging changes in the immune system. With age, the number of immune cells may decrease slightly. More important, the functioning of these cells declines. The cells are often less able to control illness than in earlier...

The Interactions Between Stress Lipid Profiles Cortisone HPA Axis and Inflammation Immunity

To our knowledge, there are many interactions between stress, lipid profiles, cortisone HPA axis, and inflammation immunity. In addition to lipid profiles and depression, we also must investigate the relationships between lipid profiles and stress, cortisone HPA axis, and inflammation immunity, as described below. 3.1. Psychological Factors Lipid Profiles and Stress Recent research on the causes of disease and aging has increasingly supported the importance of stress 101 . One theory of the...

Association of Kallikreins with Human Diseases

Some kallikrein genes have been associated with the pathogenesis of human diseases. The KLK1 gene is involved in inflammation 8 , hypertension 187 , renal nephritis, and diabetic renal disease 188 , The relationships between hK5 and hK7 and skin diseases, including pathological keratiniza-tion and psoriasis, have already been reported 189, 190 . Much research is now focusing on the relation of kallikreins to diseases of the central nervous system (CNS) and skin, as well as to malignancy, as...