Human Tissue Kallikreins From Gene Structure To Function And Clinical Applications

George M. Yousef,*' { Christina V. Obiezu,*' Liu-Ying Luo,*'{ Angeliki Magklara,* Carla A. Borgono,*'{ Tadaaki Kishi,* Nader Memari,*'{ Iacovos P. Michael,* ' Michael Sidiropoulos,*^ Lisa Kurlender,*^ Katerina Economopolou,*^ Carl Kapadia,*^ Nahoko Komatsu,* Constantina Petraki,{ Marc Elliott,*,t

Andreas Scorilas,x Dionyssios Katsaros," Michael A. Levesque,* and Eleftherios P. Diamandis*'

*Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada tDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5G 1L5, Canada ^Department of Pathology, Evangelismos Hospital, 11528 Athens, Greece xDepartment of Biochemistry and Molecular Biology, University of Athens, 15701 Athens, Greece "Department of Gynecology, Gynecologic Oncology Unit, University of Turin, 10060 Turin, Italy

  1. Introduction 12
  2. Discovery of the Human Tissue Kallikrein Gene Locus:

A Short Historical Perspective 13

  1. Kallikreins in Rodents and Other Species 13
  2. 1. The Mouse Kallikrein Gene Family 15
  3. 2. The Rat Kallikrein Gene Family 16
  4. 3. The Mastomys Kallikrein Gene Family 16
  5. 4. The Monkey and Chimpanzee Kallikrein Gene Families 17
  6. 5. The Dog Kallikrein Gene Family 17
  7. 6. Kallikreins in Other Species 17
  8. Characterization and Sequence Analysis of the Human

Tissue Kallikrein Gene Locus 18

  1. 1. Locus Overview 18
  2. 2. Repeat Elements and Pleomorphism 19

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