Sexually Transmitted Diseases

SCAT has been extensively studied for the treatment STDs, where ease of administration, tolerability, and cost has had a great influence. The literature is most robust for Neisseria gonorrhoeae and Chlamydia trachomatis infections. A recent review found clinical trial evidence for 30 regimens that were > 95% effective in eradicating gonococcal infection (103). Despite a rising incidence of antibiotic resistance among strains of N. gonorrhoeae, highly active and effective single-dose regimens are available for both of these pathogens, which support the effective use of DOT. DOT greatly increases compliance and decreases secondary transmission when compared with longer courses of antibiotic therapy.

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