Vaccination

When considering immunity, it is important to realize that there is often a difference between natural immunity that arises after repeated infections with the parasite, and vaccine-induced immunity in which the immune system of the host is trained to produce a protective immunological response that may not occur with natural infection. In the past, vaccinologists have used the principles of natural immunity for the development of live vaccines (see Anti-Parasite Vaccines below) however, with a...

Anti Disease Vaccines

With an increasing knowledge concerning the pathogenesis of a parasitic infection, the way was opened to develop vaccines that specifically aimed to prevent clinical signs, without affecting parasite proliferation per se. The existence of anti-disease immunity is already evident in malaria children first develop anti-disease immunity that does not protect them from subsequent reinfection however, during adolescence an additional protective immunity is developed with a clear anti-parasite...

From Cancer Research to Anti Apicomplexa

Members of the phylum Apicomplexa account for some of the most debilitating infections of humans and livestock. Malaria, caused by Plasmodium sp., is undoubtedly the most important infectious disease and a major cause ofdeath in developing countries. Other infections by apicomplexan parasites such as Toxoplasma gondii, Cryptosporidium parvum and Babesia sp. are usually asymptomatic in humans but become life-threatening diseases in immune-compromised patients. The latter species, as well as...

Conclusion

The discovery of novel drugs for parasitic diseases is a high-risk, expensive, and lengthy process 22 . The past few years have seen increased financial and infrastructural support for drug discovery and development for parasitic diseases by academic institutes, PPPs, and the pharmaceutical industry 3, 5 . Already this has led to imaginative, comprehensive and dynamic drug discovery and development pipelines (even in the face of sometimes modest financial backing) when compared to those...

Drug Discovery Initiatives to Accelerate the Development of Novel Anti Parasitic Drugs for Humans and Animals

Infectious diseases, including those caused or transmitted by parasites, are responsible for substantial morbidity and mortality worldwide and affect several billion people globally, particularly in developing countries 1 . Until recently, infectious diseases were viewed as a problem of the past however, the emergence of drug-resistant organisms makes the need for new drugs or vaccines more important than ever before. Moreover, as these diseases predominantly afflict inhabitants of poor...