Mode Of Action For Dma Carcinogenesis In The

Inorganic and organic arsenicals are not DNA reactive chemicals (IARC, 1980 Jacobson-Kram and Montalbano, 1985 U.S. EPA, 1997). Although they have produced positive results in a variety of genotoxicity screens, these involve mechanisms generally associated either with DNA repair, chromosomal aberrations or clastogenicity (IARC, 1980 Jacobson-Kram and Montalbano, 1985). In a few instances, possible mechanisms regarding the cause of these genotoxic alterations have been identified, but for the...

Susceptibility To Ischemic Heart Disease

In a cohort study of ischemic heart disease among residents in the BFD-endemic area, a significant biological gradient was observed between the incidence of ischemic heart disease and the cumulative arsenic exposure (Chen et al., 1996). There was also an increased incidence of ischemic heart disease for patients affected with BFD as compared with the unaffected. The status of BFD may be considered an indicator of long-term arsenic exposure, systemic atherosclerosis and or susceptibility to...

Investigation Procedures

RI FS soil samples were collected at approximately 150 locations within two miles of the Globe Plant over 0 to 5 cm and 5 to 20 cm depth intervals, based on a polar grid system that resulted in a greater sample density near the plant. The sampling program was deliberately biased or stratified to select sites with the least amount of apparent disturbance (e.g., vacant lots) to maximize the likelihood that metals due to deposition of historic air emissions would still be present and not removed...

Dma Carcinogenesis In Rats

A major impediment to furthering our understanding of the mechanisms by which arsenic causes cancer in humans has been the lack of appropriate animal models (IARC, 1980 Huff et al., 2000). Despite its recognition as a human carcinogen, the various forms of arsenic have not been widely tested in animal models, including in standard two-year bioassays. However, recently, administration of relatively high doses of dimethylarsinic acid (DMA) were demonstrated to produce an increased incidence of...

Scientific Issues

At present, arsenic pollution is one of the key public health problems of China. The major scientific researches in recent years are introduced as follows. Inorganic arsenic is an established human carcinogen and is associated with various tumors including lung, skin, and other internal cancers in exposed populations. However, generally accepted animal models for arsenic-induced cancers have not been demonstrated. Many studies have shown that arsenic can affect DNA repair and methylation,...