Biodegradable membrane artificial cells have been prepared to contain enzymes, hormones, vaccines, and other biologicals (Chang, 1976a). The detailed method is described in Appendix II. The polylactide polymer can degrade in the body into lactic acid and finally into water and carbon dioxide. Variations in preparation (see Appendix II) can result in artificial cells that releases insulin at different rates (Fig. 11.10) (Chang, 1976a).
Biodegradable drug delivery systems are now widely used in different forms ranging from microscopic to nanodimensions. They are also known as nanoparticles, nanocapsules, polymersomes, nanotubules, etc. Langer' group has written an excellent review on this topic (LaVan etal., 2002). Examples of other references include books and reviews (Malsch, 2005; Gupta and Kompell, 2006; Ranade and Hollinger, 2003; Pardridge, 2002; Duncan, 2003; and many others). As described earlier in this book, this method also forms the basis for preparing nanodimension artificial red blood cells (Chang, 2005, 2006).
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