Plasma hepatic growth factor HGF levels

In the hepatectomized groups that received artificial cells containing hepatocytes or artificial cells containing bone marrow stem cells, the

HEPATIC GROWTH FACTOR (HGF) IN PLASMA

Liu & Chang; J Liver Transplant (2006)

Liu & Chang; J Liver Transplant (2006)

0 2 4 6 8 10 12 14 DAYS POST HEPATECTOMY (HP)

Fig. 9.11. Plasma hepatic growth factor (HGF) followed for those rats that have survived for 14 days. The results are shown as Mean ± S.D. only for those groups where all the animals have survived. PH = surgical removal of 90% of the liver. BMCs = bone marrow stem cells. H = hepatocytes. Encap = in artificial cells. (Liu and Chang, 2006.)

0 2 4 6 8 10 12 14 DAYS POST HEPATECTOMY (HP)

Fig. 9.11. Plasma hepatic growth factor (HGF) followed for those rats that have survived for 14 days. The results are shown as Mean ± S.D. only for those groups where all the animals have survived. PH = surgical removal of 90% of the liver. BMCs = bone marrow stem cells. H = hepatocytes. Encap = in artificial cells. (Liu and Chang, 2006.)

blood levels of HGF peaked at days 2 and 3 post surgery, and were significantly higher than those in the other groups (Liu and Chang, 2006). After this, the levels decreased and returned to pre-surgery level on day 14. In the free hepatocytes transplantation group, the peaked level was significantly lower at day 2 post surgery, decreasing to pre-surgery level at day 7. In the control hepatectomized groups that received 1) no treatment 2) artificial cells containing no cells group; or 3) free bone marrow stem cells, the blood HGF levels were much lower (Fig. 9.11).

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