Class I Receptors the Classic Nuclear Hormone Receptors

The class I nuclear hormone receptors comprise the receptors that are activated by steroid hormones, such as estrogen, androgen, and glucocorticoids. The class I receptors, by definition, form homodimers that bind to inverted repeats (IR) of the HREs. These receptors mediate the numerous physiological responses to steroid hormones, not only

Table 6.2 Nuclear hormone receptor classes

Class I

Class II

Class III

Class IV

Response element

5'-AGAACA

5'-AGGTCA Mostly

5'-AGGTCA

5'-A A C A AGGTCA

Almost always

direct repeat DR-1,

Mostly direct

Extended half-site

inverted repeats,

DR-2, DR-3, DR-4,

repeat, bind

also with flanking

IR-3

DR-5 or IR-0, IR-1

inverted repeats

AT rich sequences

Dimerization

Homodimer

Heterodimer

Homodimer

Monomer

Ligand

Steroid Hormones

Non-Steroid hormones and other Lipid Metabolites

Unknown

Structure

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