Protein Tyrosine Kinases PTK

Receptor-and nonreceptor tyrosine kinases are also targets of oxidative stress.98 Exogenous H2O2 induces tyrosine phosphorylation and activation of PDGFR and EGFR, probably due to ROS-mediated inhibition of dephosphorylation of PDGFR and EGFR by inactivation of membrane-associated protein tyrosine phosphatase.98,99 Oxygen intermediates, which are produced in response to tyrosine kinase receptor activation, are also involved in transactivation of PDGFR and EGFR by Ang II. Under pathological conditions associated with oxidative stress, such as hypertension, ROS may directly activate cell surface receptors, thereby amplifying the process of *O2- generation. Nonreceptor tyrosine kinases such as Src, JAK2, Pyk2, and Akt, all of which have been implicated in cardiovascular remodeling and vascular damage, are also regulated by ROS.3,99101

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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