Reactive Oxygen Species Reduce NO Bioavailability

Impaired endothelium-mediated vasodilatation has been linked to decreased NO bioavailability. This may be secondary to decreased synthesis of NO and/or increased degradation of NO because of its interaction with *O2- to form ONOO.116118 Peroxynitrite is a weak vasodilator compared with NO and has pro-inflammatory potential.119 Oxygen radicals also induce endothelial permeability with extravasation of plasma proteins and other macromolecules, and recruitment of inflammatory proteins and cells, which could further impair endothelial function and aggravate vascular damage.120,121 Peripheral polymorphonuclear leukocytes, which generate *O2-, participate in oxidative stress and inflammation in patients with hypertension.112,120,121 The co-existence of an inflammatory reaction with oxidative stress induces endothelial dysfunction. Many of the redox-sensitive vascular changes that occur in hypertension also exist in atherosclerotic vessels. In fact oxidative stress-mediated vascular damage may be a link between hypertension and atherosclerosis.120

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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