Sulphonylation Methods

Another important aspect of Schotten-Baumann reaction is sulphonylation whereby benzene sulphonyl chloride, C6H4SO2Cl (i.e., the corresponding 'acid chloride' of benzene sulphonic acid, C6H4SO3OH) is employed instead of benzoyl chloride, and almost similar structural analogues may be obtained. It has been established experimentally that Schotten-Baumann sulphonylation holds good for two different types of organic compounds, namely (a) Phenols i.e., OH moiety attached directly to an aromatic...

The Retro Synthetic Approach

Invariably Example

In fact, the overall perspective and conception of a synthesis commences with a careful logical dissection of the target-drug-molecular skeleton into synthons. However, the disconnection of a bond within a monocyclic system shall be a retro-synthetic ring-opening phenomenon, otherwise termed as the retro-synthetic approach. Likewise, the disconnection of a bond caused in a bridged-structure would ultimately produce either a mono- or a di- substituted monocyclic structure. Sometimes, it may also...