Introduction

The prime objective of this book is not only to focus emphatically the multifarious and varied aspects of 'practical medicinal chemistry' with which a pharmacy professional student will need to be familiarized, but also get exposed and acquainted with the synthesis of important 'medicinal compounds'. Drug synthesis may be accomplished by the actual preparation of a wide variety of compounds involving a representative careful selection of typical documented reaction processes and latest techniques. Perhaps, logically and justifiably the prospective budding 'medicinal chemists' on the strong foot-hold of good theoretical knowledge and the various chemical, physical and spectroscopical aspects may begin to understand more vividly and explicitely the cardinal factors that essentially attribute their reactivity vis-a-vis biological activity.

'Drug design' or 'tailor-made compound' particularly aims at developing a drug with a very high degree of chemotherapeutic index and specificity of action. With the advent of latest concepts and tools evolved in 'Computer Aided Drug Design (CADD)' one may logically design a new drug molecule on as much a rational basis as possible.

It is, however, pertinent to mention here that 'medicinal chemists' have traditionally adopted synthesis as the ultimate-concrete-evidence of molecular structure(s) of natural products meticulously isolated from plant and animal sources. Over the years it has been universally accepted as an authentic and genuineproof-of-identity between an isolated natural substance and the compound produced by total-synthesis eventually confirmed the molecular structure arrived at through various physico chemical methods of analysis.

Therefore, a thorough basic concept and knowledge of 'drug synthesis' may ultimately help a medicinal chemist to produce life-saving drugs, such as : penicillin, quinine, prostaglandins, steroids, anti-neoplastic agents. In short, synthetic medicinal chemistry, with the skill, wisdom and effort, has proved to be a major endeavor not only confined to the laboratories of Universities in general, but also to the bulk-drug industry in particular.

In the past one century and a half 'research chemists' across the globe have evolved an innumerable, viable and potential synthetic routes for the preparation of any conceptualized 'target-drug-molecule'. Interestingly, in the last four decades or so the very emergence of

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