Some Progress On Chemical Studies Of Saponins From Chinese Medicinal Plants

Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200031, China Saponins occur widely in plant kingdom and possess various bioactivities such as sedative, antipyretic, analgesic, anticough, antiinflammatory, immunopromoting etc. Many commonly-used traditional Chinese medicines like ginseng, glycyrrhiza, Bupleurm, Platycodon are noted as their rich saponins, which have been studied since long time ago. By using reverse-phase chromatography and polyporous resins for...

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Saponins where extracted with 1-butanol and purified by 5 h dialysis with 3000 MW tubing bconcentrations of added saponins were 15, 150, and 450 ppm cSoils from Asian Vegetable Research and Development Center where no mungbeans were grown during the previous three years plots 41 and 42 dSmall differences of enhancement may be seen at flowering, pod maturity, not pod number. Saponins where extracted with 1-butanol and purified by 5 h dialysis with 3000 MW tubing bconcentrations of added saponins...

Biological Test On Schefflera Glycosides And Ginseng Glycosides By Radioligand Receptor Binding Assays

Department of Pharmacy, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong Abstract Schefflera bodinieri was studied for its activity in the central nervous system by bioassay guided isolation in conjunction with receptor binding assays. In preliminary screening, ethanol extracts of leaves and roots of S. bodinieri were shown to have strong binding affinity to al- and a2-adrenergic, 5HT-1, 5HT-2, opiate, Ca+2 channel, sulphonylureas, dopamine 1 and 2, histamine 1, GABAa and GAB A...

Cancer Chemopreventive Activities Of Panax Notoginseng And Ginsenoside Rg11

Kyoto Pharmaceutical University, Msasagi, Yamashina-ku, Kyoto 607, Japan Currently, although many kinds of anti-tumor agents are developed and the medicinal sciences make rapid progress in the treatment of cancer, cancer is the most tragic disease and one of the major cause of death in the world. Therefore, the advancement of cancer chemoprevention is very important as well as the development of cancer treatment. The mechanism of chemical carcinogenesis has been explained by either a two-stage...

Tibet Plateau

Northwest Plateau Institute of Biology ,The Chinese Academy of Sciences, Xining, Key Word Index Gentianaceae Xanthone glycosides Hepatitis Cholecystitis Tibetan Abstract Most species of Gentianaceae in Qinghai-Tibet Plateau are traditional Tibetan medicines which were used for stabilizing liver functions and improving the gallbladder. They were used for curing hepatitis, cholecystitis and other diseases. We have studied the chemical composition of 12 species of Gentianaceae and extracted 17...

New Neohopane Triterpenoidal Saponin Glycosides From Glimus Lotoids Var Dectamnoids

Faculty of Science, South Valley University, Aswan 81528, Egypt *Faculty of Pharmacy, Assuit University, Assuit 71526, Egypt. Key Word index Glirtus lotoids var. dectaminoids, Molluginaceae neohopane, triterpenoidal Abstract Two neohopane triterpenoidal saponins(glinusides D and E) were isolated from the n-butanol fraction of Glinus lotoids var. dectaminoids, their structures elucidated as 3-00 -L-arabinopyranosyl -22-0- P -D-glucopyranosyl (4 l)-a-L-rhamnopyranosyl-16- 0 -hydroxy-5- 0...

Synthesis Of Steroid Saponins From Chinese Herbs

Biao Yu,* Meizheng Liu, Chuan Li, Shaojiang Deng, and Yongzheng Hui* State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032,China Abstract Several bioactive monodesmosidic steroid saponins from traditional Chinese herbs were synthesized by glycosylating a steroid either directly with a fabricated oligosaccharide donor or stepwisely with monosaccharide donors._ Saponins constitute a...

Triterpenoid Saponins From Aster A Uricula

Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, People's Republic of China Key Word Index Aster auriculatus, Compositae triterpenoid saponins 2D NMR. Abstract Two new triterpenoid saponins were isolated from the alcoholic extract of roots of Aster auriculatus. Their structures have been determined on the basis of spectral and chemical evidence as acid-28-O-a-L-arabino-pyranosyl( 1 -4)-a-L-rhamnopyranosyl(...

Hairy Root Culture Of Panax Japonicus Var Major And Its Saponin Formation

Li-Gang Zhou, Hong-Tao Zhu, Hong Hu and Chong-Ren Yang+ Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China Key words Panax japonicus var. major, hairy roots, saponin, oligosaccharins_ Abstract A hairy root strain has been established from the root explants of P. japonicus var. major by using a wild strain pRi 15834 of Agrobacterium rhizogenes. Experimental data on the time-course of hairy root growth and saponin formation in suspension culture indicate that both the...

Phenylpropanoid Glycosides From Illicium Plants

Isao Kouno, Zhi-Hong Jiang, Chun-Shu Yang* and Takashi Tanaka Faculty of Pharmaceutical Sciences, Nagasaki University, Nagasaki 852, JAPAN * Beijing University of Traditional Chinese Medicine, Beijing 100029, CHINA Abstract Two glycerol phenylpropanoid glucosides 1, 2 and a glycoside of 2-hydroxyphenylpropanoid 3 were isolated from the barks of Illicium difengpi K. I. B. et K. I. M. (Illiciaceae). Compounds 4 and 5, the analogous compounds of 3, were obtained from the fresh fruits of I....

New Glycosides From Herxiaria Fontanesii

Addi Na t Mbark1, Zoubida Charrouf1 Dominique Guillaume2 and Ossarath KoP 1. Laboratoire de Chimie des Plantes. Facult des Sciences B P. 1014 Rabat Morocco. 2. Laboratoire de Chimie Th rapeutique, URA 1310 du CNRS. Facult des Sciences Pharmaceutiques et Biologiques, 4 Av. de l'Observatoire, 75270 Paris Cedex 06, France. 3. Laboratoire de Chimie Biologique et UMR N 111 du CNRS, Universit des Sciences et Technologies de Lille, 59655 Villeneuve d'Ascq Cedex, France. Abstract Herniaria fontanesii...

Saponins Produced During The Life Cycle Of Mungbeans And Their Role As Allelochemicals

Chen,3 C.H. Su, 3 R.M. Liou,3 S.C. Wu,3 C.C. Young,3 M.R. Lee,4 J.S. Lee,4 C.S. Cheng,2 C.H. Chou,2 and D. Kim5 1 Department of Biochemistry and Molecular Biology, Oklahoma Agricultural Experiment Station, Oklahoma State University, Stillwater, Oklahoma 74078, 2Institute of Botany Academia Sinica, Taipei, Taiwan, 3Department of Soil Science, and 4Department of Chemistry, National Chung Hsing University, Taichung, Taiwan, 5Asian Vegetable Research and Development...

Leguminous Glycosides Effective For Hepatitis

Faculty of Pharmaceutical Sciences, Kumamoto University, Oe-honmachi 5-1, From the reason that leguminous plants so widely distribute and are used as foodstuffs and folk medicines, we have focused on these plants and are trying to develop natural medicines after proving the effectiveness of these crude drugs and to find the lead compounds among these natural source. As presented in the preceding ACS Saponin Symposium in Chicago 1995 1 , we reported the oleanene glucuronides in Abri Herba and...

Contributors

Department of Chemistry Boston University 590 Commonwealth Ave. Boston, MA 02215, U.S.A. Laboratory of Natural Materia Medica Chengdu Institute of Biology Chinese Academy of Sciences Chengdu, 610041, P. R. China Zoubida Charrouf Laboratoire de Chimie des Plantes Facult des Sciences B P. 1014 Rabat, Morocco Department of Soil Science National Chung Hsing University Taichung, Taiwan Department of Natural Product Chemistry Shenyang Pharmaceutical University Wenhua Road 103, Shenyang 110015 PR....

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Wuhan Institute of Botany Chinese Academy of Sciences Wuhan 430074 P. R. China Joint Research Center, Kinki University Kowakae 3-4-1 Higashi-Osaka 577 Japan Toshiyuki Murakami Kyoto Pharmaceutical University 5 Nakauchi-cho, Misasagi Yamashina-ku, Kyoto 607 Japan Toyama Medical & Pharmaceutical University HCMC University of Medicine and Pharmacy 41 Dinh Tien Hoang Street, District 1 Yoshinobu Nochika Department of Applied Chemistry Faculty of Science and Engineering Kinki University 3-4-1,...

Some Edible Vegetables Of Saponin Containing Indigenous To China

Chemical Research Department of Natural Medicine, Kunming Medical College, Kunming In the past, people have always considered the toxicity of saponin, but many kinds of vegetables, melons and fruits containing saponins have been demonstrated by modern scientific research. Those saponins belong to pentacyclic triterpene, tetracyclic triterpene and steroidal structures respectively. In the present report saponins from some vegetables, melons and fruits used to be eaten in china were disscused as...

Antineoplastic Steroidal Saponins From Rhizomes Of Dioscorea Collettiivar Hypoglauca

Ke Hu, Ai-Jun Dong,* Xin-Sheng Yao, Hisayoshi Kobayashi f And Shigeo Iwasaki f Department of Natural Products Chemistry, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, P. R. China 110015 * Institute of Northeast General Pharmaceutical Corporation, 37 Zhonggong Beijie, Shenyang, P. R. China 11026 Institute of Molecular and Cellular Biosciences, The University of Tokyo, Yayoi, Bunkyo-ku, Tokyo, Japan 113. Key Word nAt Dioscorea collettii var. hypoglauca, Dioscoreaceae steroidal...

New Triterpenoid Glycosides From Decaianea Fa Rgesi I

Jie Kong, Quan Xia , Yun-Qu Wang, Chong-Ren Yang and Han-Qing Wang Botany Institute, Northwest Normal University, Lanzhou, Gansu, 730070, P.R. China Institute of Medicinal Plant, Chinese Academy of Medical Sciences, Xibeiwang, Haidian District, 10094, Beijing, P.R. China , Laboratory of phytochemistiy, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming Yunnan, 650204, P.R.China , Institute of Physical Chemistry Chinese Academy of Sciences, Lanzhou Gansu, 730010, P.R.China ....

Two New Sesquiterpene Glucosides From Ixseris Plants

Ji-Yuan Ma, f Ai-Ming He, f De-Cheng Zhang, f Zhen-Tao Wang, Luo-Shan Xu, J Guo-Jun Xu, i Tsuneo Namba and Shigetoshi Kadota tShanghai Representative Office, Generation Health Co., Shanghai Medical University, 200032, Shanghai, China Department of Pharmacognosy, China Pharmaceutical University, No 1 Shennong Rd. Nangjing, 210038, China Toyama Medical amp Pharmaceutical University, Key Word Indtx Ixeris denticulata f. pinnatipartita Kitag. I. sonchifolia Hance Compositae sesquiterpene lactone...

Derivatives

Yuan-Hong Zhao, Fu-You Yang, Kun Gu, Rui-Ying Li and Jing-Kun Wang Pharmaceutical Reseach Centre, Yunnan University, Kunming, PRC, 650091 Yunnan Province Centre For Pharmaceutical Quality Control, Kunming, PRC, 650051 Key words Index podohyllotoxin glucoside, catalytic agent, alcoholysic reaction, anticancer Abstract Podophyllotoxin glucoside derivatives Etoposide, Teniposide etc. were synthesized from Podohyllotoxin by 5 steps of reactions. The method has many advantages, such as no need of...

New Flavonoid Glycosides From Scutellaria Amoena

Zhi-Hong Zhou, Ying-Jun Zhang and Chong-Ren Yang Laboratory of Phytochemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Key Word Index Labiatae Scutellaria amoena flavonoids._ Abstract Three new flavonoid glycosides, 5,7,2'-trihydroxy-6-methoxyflavone 7-0- 3-D-glucuronide methyl ester, 5,7,2'-trihydroxy-6-methoxyflavone 7-0-3-D-glucoside and 5,7,2',6'-tetrahyroxyflavonol 2'-0-P-D-glucoside, along with eleven known flavonoids and two known phenyl ethanoid glycosides, were...

Separation Of Three Major Isoflavonoids From The Root Of Pueraria Lobata By High Speed Centrifugal Partition

Department of Natural Drug, Shenyang Pharmaceutical University, Shenyang 110015 China Natural Pharmacia International Inc., Research Triangle Park, NC27709 USA Key Word ndtx-Pueraria lohata, isoflavonoids HSCPC_ Abstract-High Speed Centrifugal Partition Chromatography HSCPC was applied for the first time in the preparative scale separation of isoflavonoids from Pueraria lobata Ohwi. The three major isoflavonoids in the root of Pueraria lobata, puerarin, 3'-methoxypuerar in and daidzin were...