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Figure 1 Antibody memory is engraved by AID. Three genetic alterations occur in the IgH locus. (Top) The first genetic alteration, VDJ recombination assembles V, D, and J gene segments to produce a single productive V exon in each B cell, generating V region repertoire in each individual. VDJ recombination that occurs in bone marrow on B-cell development is mediated by RAG-1 and RAG-2 recombinases that are expressed by differentiation program of B cells. (Bottom) After completion of VDJ...