Mean levels of ROOH of 9.04 ± 4.3 and 9.4 ± 3.3 |^mol/L were detected in freshly prepared plasma from type II diabetics from two different studies (/? = 22 and 87, respectively) (17,18). The corresponding levels for healthy volunteers from three different studies were 3.02 ± 1.85, 3.76 ± 2.48, and 4.1 ± 2.2 |imol/L (n = 23, 21, and 41, respectively) (16-18). Data spread for plasma ROOHs and ratio of ROOHs/cholesterol standardized a-tocopherol in NIDDM and control subjects are shown in Figure 3. Clinical characteristics of NIDDM and control subjects are summarized in Table 1. Similar plasma ROOH concentrations have also been reported by other investigators using the FOX2 assay (20-22). These data together provide the evidence for the reliability of the FOX2 assay for the measurement of plasma ROOHs.
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