1. Ybarra J, Lopez-Talavera JC. Non insulin dependent diabetes mellitus, lipid metabolism and atherosclerosis [editorial]. Med Clin (Bare) 1998; 110:19-21.
  2. Valek J. Prevention of atherosclerosis in diabetics. Cas Lek Cesk 1997; 136: 523-526.
  3. Steiner G. Diabetes mellitus, dyslipoproteinaemias and atherosclerosis. Diabeto-logia 1997; 40:S147-S148.
  4. Visseren FL, Bouter KP, Pon MJ, Hoekstra JB, Erkelens DW, Diepersloot RJ. Patients with diabetes mellitus and atherosclerosis: a role for cytomegalovirus? Diabetes Res Clin Pract 1997; 36:49-55.
  5. Bornfeldt KE, Raines EW, Nakano T, Graves LM, Krebs EG, Ross R. Insulinlike growth factor-I and platelet-derived growth factor-BB induce directed migration of human arterial smooth muscle cells via signaling pathways that are distinct from those of proliferation. J Clin Invest 1994; 93:1266-1274.
  6. Gilbert RE, Cox A, Wu LL, Allen TJ, Hulthen UL, Jerums G, Cooper ME. Expression of transforming growth factor-beta 1 and type IV collagen in the renal tubulointerstitium in experimental diabetes: effects of ACE inhibition. Diabetes 1998; 47:414-422.
  7. Park IS, Kiyomoto H, Abboud SL, Abboud HE. Expression of transforming growth factor-beta and type IV collagen in early streptozotocin-induced diabetes. Diabetes 1997; 46:473-480.
  8. Sumida Y, Ura H, Yano Y, Misaki M, Shima T. Abnormal metabolism of type-IV collagen in normotensive non-insulin-dependent diabetes mellitus patients. Horm Res 1997; 48:23-28.
  9. Karasu C, Ozansoy G, Bozkurt O, Erdogan D, Omeroglu S. Antioxidant and triglyceride-lowering effects of vitamin E associated with the prevention of abnormalities in the reactivity and morphology of aorta from streptozotocin-diabetic rats. Antioxidants in Diabetes-Induced Complications (ADIC) Study Group. Metabolism 1997; 46:872-879.
  10. Gazis A, Page S, Cockcroft J. Vitamin E and cardiovascular protection in diabetes [editorial]. Br Med J 1997; 314:1845-1846.
  11. Siman CM, Eriksson UJ. Vitamin E decreases the occurrence of malformations in the offspring of diabetic rats. Diabetes 1997; 46:1054-1061.
  12. Viana M, Herrera E, Bonet B. Teratogenic effects of diabetes mellitus in the rat. Prevention by vitamin E. Diabetologia 1996; 39:1041-1046.
  13. Shklar G, Schwartz JL. Vitamin E inhibits experimental carcinogenesis and tumour angiogenesis. Eur J Cancer B Oral Oncol 1996; 32B: 114—119.
  14. Pentland AP, Morrison AR, Jacobs SC, Hruza LL, Hebert JS, Packer L. Tocopherol analogs suppress arachidonic acid metabolism via phospholipase inhibition. J Biol Chem 1992; 267:15578-15584.
  15. Lucy JA. Functional and structural aspects of biological membranes: a suggested structural role for vitamin E in the control of membrane permeability and stability. Ann NY Acad Sci 1972; 203:4-11.
  16. Gillilan RE, Mondell B, Warbasse JR. Quantitative evaluation of vitamin E in the treatment of angina pectoris. Am Heart J 1977; 93:444-449.
  17. Briggs M. Are vitamin E supplements beneficial? Med J Aust 1974; 1:434437.
  18. Diplock AT, Xu GL, Yeow CL, Okikiola M. Relationship of tocopherol structure to biological activity, tissue uptake, and prostaglandin biosynthesis. Ann NY Acad Sci 1989; 570:72-84.
  19. Hentati A, Deng HX, Hung WY, Nayer M, Ahmed MS, He X, Tim R, Stumpf DA, Siddique T, Ahmed. Human alpha-tocopherol transfer protein: gene structure and mutations in familial vitamin E deficiency. Ann Neurol 1996; 39:295-300.
  20. Doerfiinger N, Linder C, Ouahchi K, Gyapay G, Weissenbach J, Le Paslier D, Rigault P, Belal S, Ben Hamida C, Hentati F, et al. Ataxia with vitamin E deficiency: refinement of genetic localization and analysis of linkage disequilibrium by using new markers in 14 families. Am J Hum Genet 1995; 56:11161124.
  21. Ouahchi K, Arita M, Kayden H, Hentati F, Ben Hamida M, Sokol R, Arai H, Inove K, Mandel JL, Koenig M. Ataxia with isolated vitamin E deficiency is caused by mutations in the alpha-tocopherol transfer protein. Nat Genet 1995; 9:141-145.
  22. Tasinato A, Boscoboinik D, Bartoli GM, Maroni P, Azzi A. ¿/-Alpha-tocopherol inhibition of vascular smooth muscle cell proliferation occurs at physiological concentrations, correlates with protein kinase C inhibition, and is independent of its antioxidant properties. Proc Natl Acad Sci USA 1995; 92:1219012194.
  23. Boscoboinik D, Ozer NK, Moser U, Azzi A. Tocopherols and 6-hydroxy-chro-

man-2-carbonitrile derivatives inhibit vascular smooth muscle cell proliferation by a nonantioxidant mechanism. Arch Biochem Biophys 1995; 318:241-246.

  1. Boscoboinik DO, Chatelain E, Bartoli GM, Stauble B, Azzi A. Inhibition of protein kinase C activity and vascular smooth muscle cell growth by ¿/-alpha-tocopherol. Biochim Biophys Acta 1994; 1224:418-426.
  2. Chatelain E, Boscoboinik DO, Bartoli GM, Stauble B, Azzi A. Inhibition of smooth muscle cell proliferation and protein kinase C activity by tocopherols and tocotrienols. Biochim Biophys Acta 1993; 1176:83-89.
  3. Muller R, Mumberg D, Lucibello FC. Signals and genes in the control of cell-cycle progression. Biochim Biophys Acta 1993; 1155:151-179.
  4. Azzi A, Boscoboinik D, Hensey C. The protein kinase C family. Eur J Biochem 1992; 208:547-557.
  5. Newton AC. Protein kinase C: structure, function, and regulation. J Biol Chem 1995; 270:28495-28498.
  6. Mellor H, Parker PJ. The extended protein kinase C superfamily [In Process Citation], Biochem J 1998: 332:281-292.
  7. Korinek V, Barker N, Morin PJ, van Wichen D, de Weger R, Kinzler KW. Vogelstein B, Clevers H. Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma. Science 1997; 275:1784-1787.
  8. Morin PJ, Sparks AB, Korinek V, Barker N, Clevers H, Vogelstein B, Kinzler KW. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 1997; 275:1787-1790.
  9. Rubinfeld B, Robbins P, El-Gamil M, Albert I, Porfiri E, Polakis P. Stabilization of beta-catenin by genetic defects in melanoma cell lines. Science 1997; 275: 1790-1792.
  10. Matsushima H, Shimohama S, Tanaka S, Taniguchi T, Hagiwara M, Hidaka H, Kimura J. Platelet protein kinase C levels in Alzheimer's disease. Neurobiol Aging 1994; 15:671-674.
  11. Kinouchi T, Sorimachi H, Maruyama K, Mizumo K. Ohno S, Ishiura S, Suzuki K. Conventional protein kinase C (PKC)-alpha and novel PKC epsilon, but not delta, increase the secretion of an N-terminal fragment of Alzheimer's disease amyloid precursor protein from PKC cDNA transfected 3Y1 fibroblasts. FEBS Lett 1995; 364:203-206.
  12. Boyce JJ, Shea TB. Phosphorylation events mediated by protein kinase C alpha and epsilon participate in regulation of tau steady-state levels and generation of certain "Alzheimer-like" phospho-epitopes. Int J Dev Neurosci 1997; 15:295307.
  13. Govoni S, Racchi M, Bergamaschi S, Trabucchi M, Battaini F, Bianchetti A, Binetti AG. Defective protein kinase C alpha leads to impaired secretion of soluble beta-amyloid precursor protein from Alzheimer's disease fibroblasts. Ann NY Acad Sci 1996; 777:332-337.
  14. Haller H, Lindschau C, Quass P, Distler A, Luft FC. Differentiation of vascular smooth muscle cells and the regulation of protein kinase C-alpha. Circ Res 1995; 76:21-29.
  15. Wang S, Desai D, Wright G, Niles RM, Wright GL. Effects of protein kinase C alpha overexpression on A7r5 smooth muscle cell proliferation and differentiation. Exp Cell Res 1997; 236:117-126.
  16. Leng L, Du B, Consigli S, McCaffrey TA. Translocation of protein kinase C-delta by PDGF in cultured vascular smooth muscle cells: inhibition by TGF-beta 1. Artery 1996; 22:140-154.
  17. Schaffer SW, Ballard C, Mozaffari MS. Is there a link between impaired glucose metabolism and protein kinase C activity in the diabetic heart? Mol Cell Biochem 1997; 176:219-225.
  18. Malhotra A, Reich D, Reich D, Nakouzi A, Sanghi V, Geenen DL, Buttrick PM. Experimental diabetes is associated with functional activation of protein kinase C epsilon and phosphorylation of troponin I in the heart, which are prevented by angiotensin II receptor blockade. Circ Res 1997; 81:1027-1033.
  19. Ishii H, Jirousek MR, Koya D, et al. Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor. Science 1996; 272:728-731.
  20. Chan AC, Tran K. The uptake of (R, R, R)alpha-tocopherol by human endothelial cells in culture. Lipids 1990; 25:17-21.
  21. Konneh MK, Rutherford C, Li SR, Anggard EE, Ferns GA. Vitamin E inhibits the intimal response to balloon catheter injury in the carotid artery of the cholesterol-fed rat. Atherosclerosis 1995; 113:29-39.
  22. Sirikci O, Ozer NK, Azzi A. Dietary cholesterol-induced changes of protein kinase C and the effect of vitamin E in rabbit aortic smooth muscle cells. Atherosclerosis 1996; 126:253-263.
  23. Porreca E, Ciccarelli R, Di Febbo C, Cuccurullo F. Protein kinase C pathway and proliferative responses of aged and young rat vascular smooth muscle cells. Atherosclerosis 1993; 104:137-145.
  24. Alexander DR, Graves JD, Lucas SC, Cantrell DA, Crumpton MJ. A method for measuring protein kinase C activity in permeabilized T lymphocytes by using peptide substrates. Evidence for multiple pathways of kinase activation. Biochem J 1990; 268:303-308.
  25. Azzi A, Boscoboinik D, Marilley D, Ozer NK, Stauble B, Tasinato A. Vitamin E: a sensor and an information transducer of the cell oxidation state. Am J Clin Nutr 1995; 62:1337S-1346S.
  26. Martiny-Baron G, Kazanietz MG, Mischak H, Blumberg PM, Kochs G, Hug H, Marme D, Schachtele C. Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976. J Biol Chem 1993; 268:9194-9197.
  27. Muller G, Ayoub M, Storz P, Rennecke J, Fabbro D, Pfizenmaier K. PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid. EMBO J 1995; 14:1961-1969.

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