Advances In Agents Of Known Mechanism Of Action

Allvlamines - The allylamine mechanism of action reversibly inhibits squalene epoxidase, a key enzyme in ergosterol biosynthesis, resulting in accumulation of intracellular squalene, which blocks new sterol synthesis and diminishes membrane ergosterol content. The best-known compound is terbinafine (Lamisil, 19) that is available as both an oral formulation and a topical preparation for the treatment of dermatophyte infections (37,38). Terbinafine has good antifungal activity against C. albicans and the maleate salts are used for the systemic and topical treatment of fungal infections, especially fungal sinusitis infection and onychomycosis (39,40).

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