Ghrelin Antagonists

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Chapter 10. Current and future gastrointestinal prokinetic agents

M. Chovet and L. Bueno* Pfizer Global R&D, Fresnes, France * Department of Neurogastroenterology, INRA, Toulouse, France

Introduction - Gut dysmotility involves both myogenic and neuronal mechanisms corresponding to modifications of smooth muscle contractility (phasic or tonic contractions) or motor coordination (altered motor pattern). Prokinetic agents are drugs able to stimulate smooth muscle contractility or to modulate gastroduodenal motor coordination. These actions are of particular interest in the treatment of 1) dyspesia, a major gastroduodenal disorder centered in the upper abdomen where gastrointestinal hypomotility is often associated with symptoms such as discomfort or pain and 2) constipation which is defined by a lower gastrointestinal (bowel) transit impairment ending in altered stools or defecations.

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