Oxazines analogs, such as 25, were claimed as potentially effective against migraine and associated pain (48,49). Subsequently, a series of aminopyrimidines, e.g., 26, was disclosed that exhibited picomolar activity for the mGluRI receptor (IC5o value <1 nM) as well as activity against formalin-induced pain and in a migraine model of dural protein extravasion (50).
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Are Headaches Taking Your Life Hostage and Preventing You From Living to Your Fullest Potential? Are you tired of being given the run around by doctors who tell you that your headaches or migraines are psychological or that they have no cause that can be treated? Are you sick of calling in sick because you woke up with a headache so bad that you can barely think or see straight?