Melanin-Concentrating Hormone Receptor - While it has been known for some time that the cyclic 19-amino peptide Melanin-concentrating hormone increases food intake when injected intracerebroventricularly, the Melanin-concentrating hormone receptor (MCH1R) responsible for this activity has only recently been identified (44). Mice carrying knockouts of the MCH1R gene have a normal body weight, but are lean (less body fat), hyperphagic and have altered metabolism (45,46). Most importantly, MCH1R knockout mice are resistant to obesity induced by high fat diets. Recent reports describe two selective and potent MCH1R antagonist, T-226296 20 and SNAP7941 21 (47, 48).
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