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Lastly, additional structurally different mGluR5 antagonists such as phenylethynyl-, imazo-[1,2-a]-pyridine-, and 4-aminopyrimidine-derivatives, 33 (IC50 = 0.011 nM), 34 (IC50 = 0.11 nM), and 35 (IC50 = 0.12 nM), respectively, were disclosed as highly selective and potent mGluR5 antagonists (61-63).

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