Both these medications have only moderate long-term efficacy and have prescription limiting side effects. Two other medications that have been widely prescribed for obesity are Phentermine 3 (alone or in combination with fenfluramine), Mazindol 4, and Diethylpropion.
A comprehensive list of all medications for obesity is outside of the scope of this article (7-10), but as with Meridia and Xenical, all current or past therapeutics have had limited effect on obesity or its co-morbidities, and are associated with a long history of safety concerns. The poor efficacy and safety issues have, no doubt, limited the current size of the obesity therapeutic market.
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