Several heterocyclic series of compounds have been recently disclosed as mGluRI antagonists. Novel aryl carboxamide derivatives, specifically quinoxaline analogs such as 21, were claimed as mGluRI antagonists, but no biological data were disclosed (43). Quinoline analogs, such as 22, had an IC5o value of 2.97 nM at the mGluRI receptor as well as being efficacious in a cold allodynia test in rats with nerve ligation (Bennett model), exhibiting antagonism at a dose of 2.5 mg/kg (44).



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