resistance mutations, a novel active site mutation at position 28(A-S) was also uncovered (37). In vitro selection pressure experiments suggest a higher genetic barrier to resistance exists for TMC-114 than that for several approved Pi's. Selected resistant viruses contained mutations at positions 41(R-T) and 70(K-E). These viruses were moderately resistant to TMC-114 but replicated poorly (38).
Was this article helpful?