Info

Conclusion - Prokinetic agents are promizing agents for the treatment of functional Bowel Disorders but until now their use was limited related to a poor prokinetic activity and side effects. Moreover, they are dedicated to selected patients according to a recognized classification such as ROME II classification for Functional Dyspepsia and Irritable Bowel Syndrome. For both syndromes about 30 to 50 % of patients may exhibit a motor defect that can be treatted by prokinetic agents. Among them, the agents targetting 5-HT receptors and particularly selective 5-HT4 receptor agonists are just entering the market with encouraging results. However, abdominal pain remains the major symptom in Functional Bowel Disorders and the efficacy of prokinetic agents on this symptom remains to be documented.

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Chapter 11. Urotensin-ll Receptor Modulators

Dashyant Dhanak, Michael J. Neeb and Stephen A. Douglas GlaxoSmithKline Pharmaceuticals King of Prussia, PA 19406-0939

Introduction - Human urotensin-ll, 1_, a cyclic undecapeptide was first isolated as the corresponding piscine analog in the 1960's from a vestigial organ in teleost fish (1) where it has been proposed to be involved primarily in osmoregulation (2 - 4). Subsequent efforts have led to the identification of urotensin-ll (U-ll) isoforms from a variety of species including frog, mouse, rat, pig, monkey and human (5 -10).

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Herbal Remedies For Acid Reflux

Herbal Remedies For Acid Reflux

Gastroesophageal reflux disease is the medical term for what we know as acid reflux. Acid reflux occurs when the stomach releases its liquid back into the esophagus, causing inflammation and damage to the esophageal lining. The regurgitated acid most often consists of a few compoundsbr acid, bile, and pepsin.

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