Gestational Trophoblastic Disease

Aylwin and A. Mitchell Gestational trophoblastic disease (GTD) includes a spectrum of cellular proliferation of trophoblasts ranging from the various forms of hydatidiform mole (complete and partial) through invasive moles and the malignant trophoblastic tumours choriocarcinomas to placental site trophoblastic tumours (PSTTs). Gestational trophoblastic tumour (GTT) is the term used for denoting those conditions that require more active intervention, usually...

Chemotherapy

In 1999 two large randomized prospective studies concluded that chemotherapy administered along with radiation significantly improved survival compared to radiation alone.16,20 As a result the standard of care has shifted to treatment involving concurrent chemotherapy with radiation therapy.15 Patients with poor performance status, co-morbid medical conditions or metastatic disease need to be evaluated on a case-by-case basis as to the additional benefits of radiation. Chemotherapy is indicated...

Clinical evidence of lymphadenopathy

If the groin nodes are grossly enlarged and either fixed or ulcerated, histological confirmation of the diagnosis is advisable. Surgical excision should be considered for all macroscopic enlarged nodes in the groin and enlarged nodes seen on CT prior to radiotherapy. A full inguinofemoral lymphadenectomy should be avoided in order to avoid severe lymphoedema. If the nodes are deemed not resectable, pre-operative radiotherapy with or without chemotherapy is advised. This should then be followed...

Endometrial cancer

Gynecological Blog

Hardesty LA, Sumkin JH, Hakim C et al. The ability of helical CT to preoperatively stage endometrial carcinoma. Am J Radiol 2001 Mar 176 3 603-6. 12. Kinkel K, Kahi Y, Yu KK et al. Radiologic staging in patients with endometrial cancer a meta-analysis. Radiology 1999 Sep 212 3 711-8. 13. Cunha TM, Felix A, Cabral J. Preoperative assessment of deep myometrial and cervical invasion in endometrial carcinoma comparison of magnetic resonance imaging and gross visual inspection, hit J Gynecol...