Help For Hearing Loss Sufferers

Hearing Aids Inside Out

Hearing Aids Inside Out

Have you recently experienced hearing loss? Most probably you need hearing aids, but don't know much about them. To learn everything you need to know about hearing aids, read the eBook, Hearing Aids Inside Out. The book comprises 113 pages of excellent content utterly free of technical jargon, written in simple language, and in a flowing style that can easily be read and understood by all.

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Breaking The Sound Barriers

Living with a deaf child is one of the hardest things that you will ever deal with in your life; the barriers to their learning and potential happiness can seem like you will never cross them. However, it is easier than you thing to learn how to communicate with your deaf child on a level that you both are able to understand. This ebook guide is designed to teach you how to truly communicate with your child so that it minimizes frustration for both of you, and allows you child to learn at a much higher level than almost anyone would have believed. You will also hear the success stories of deaf children that have gone on to achieve amazing success in their lives. Having a deaf child is a blessing, not a curse. This guide will show you how best to love and care for your child!

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Author: Julie Postance
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Highly Recommended

The writer has done a thorough research even about the obscure and minor details related to the subject area. And also facts weren’t just dumped, but presented in an interesting manner.

Purchasing this book was one of the best decisions I have made, since it is worth every penny I invested on it. I highly recommend this to everyone out there.

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Hearing Sense Recovery

This product was created by Mark after he had gone through an experienceof getting his wife's hearing back. He was contacted by one of the most brilliant researchers on the topic of getting one's hearing back and he was able to conduct a research with him in the African tribes in Kenya, the superfoods they have used have made them become the country with the least hearing loss in the world. They have made an experiment on Mark's wife who was able to get her hearing back in merely three weeks. After that, Mark has decided to put the information out to the world so they can help their hearing and the hearing of their loved ones to finally experience life as it truly should. He put the information into an easy step by step guide that walks you through every single phase you have to go through to improve the hearing. The method is very easy to attain and it does not need any technical knowledge, you can easily get this product and you will be able to get your hearing back in just three weeks. The method that is used is also natural and safe and it definitely works no matter how bad the hearing condition is, it will heal and strengthen the cells responsible for hearing.

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Contents: Ebook
Author: Mark Allen
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Autosomal Recessive Nonsyndromic Deafness

The hereditary component of hearing is extremely heterogeneous, with over 60 different genes contributing directly or indirectly to deafness. Hearing loss can be one of a number of symptoms (syndromic deafness) or the only clinical feature (nonsyndromic deafness). About 70 of all cases of inherited deafness are nonsyndromic and, of these, 75 are autosomal recessive (AR). The GJB2 gene (also designated DFNB1) that encodes gap junction protein con-nexin 26 is mutated in about half the cases of AR nonsyndromic deafness. Connexin 26 molecules form hexameric cylindrical cell surface structures that bind with other connexin 26 hexamers in adjacent cells to form channels that facilitate potassium ion exchange between cells. DNA sequencing studies of individuals with nonsyndromic deafness indicated that one-third of them had a single GJB2 mutation, that is, they were heterozygotes. In these cases, a second mutation at another locus was a likely possibility. In some of these GJB2...

Hearing Loss

Aging and excessive exposure to loud noise are the most common causes of hearing loss. Other factors such as viral or bacterial infections, an inherited disorder, or a benign tumor in the ear also can produce hearing loss. One in 10 people in the United States has a hearing loss severe enough to affect his or her ability to hear normal speech. After age 50, most people have some degree of hearing loss. The changes occur very gradually and usually go unnoticed until a family member or friend mentions the person's hearing problems. Among older people, a third of those between ages 65 and 74 and half of those over age 85 have hearing loss. There are two main types of hearing loss conductive hearing loss and sensorineural hearing loss. Conductive hearing loss occurs when something, such as a buildup of earwax or an abnormality in the eardrum, prevents sound waves from being transmitted to the inner ear. This type of hearing loss can sometimes be corrected with medication or surgery....

Jun Nterminal kinase inhibitors

JNK, a mitogen-activated kinase, has been shown to play a role in neuronal death. The JNK pathway is an important mediator of cell death. It is activated in focal cerebral ischemia in the mouse and mediates neuronal death. This is supported by the protection of JNK3 knockout mice from kainic-acid-induced seizures, apoptosis and ischemia 70,71 . Thus, JNK inhibition is a target to prevent neurotoxicity following excess excitatory amino acid release, as seen following acute ischemia 72 . Several studies have demonstrated the benefits of peptide inhibitors of JNK in experimental models of ischemic stroke, traumatic nerve injury, neurodegenerative diseases and hearing loss 72,73 . In recent published results the neuroprotective action of D-JNKI1, a cell penetrating and protease-resistance peptide selectively inhibiting the c-Jun-N-terminal kinase, was demonstrated 74 . D-JNKI1 was shown to provide neuroprotection in two models of mild focal cerebral ischemia 30 min endoluminal ( suture )...

Otitis Media With Effusion

OME is a common cause of mild hearing loss in children, most often between the ages of two and seven years. The middle ear contains fluid that varies from a thin transudate to a very thick consistency (glue ear). Eustachian tube obstruction is usually caused by primary congenital tube dysfunction. Other possible contributing factors are allergic rhinitis, adenoidal hyperplasia, supine feeding position, or a submucous cleft. Middle-ear effusion was found to persist for at least one month in up to 40 of children who had suffered from AOM, and for at least three months in 10 of afflicted children (27).

Common cold virus See human rhinoviruses

Congenital rubella syndrome Although rubella is usually a trivial childhood exanthem, if infection occurs in utero during the first 3 months of pregnancy, 20 of infected infants are born with one or more multiple severe congenital abnormalities, including neurosensory deafness, total or partial blindness, congenital heart disease and microcephaly with mental retardation. There may also be bone translucency, retardation of growth, hepatosplenomegaly and throm-bocytopenic purpura. Vaccination of girls age 15 months against rubella as part of

Chronic Mastoiditis

The onset of this infection is insidious. Clinically, there is a persistent painless, purulent, foul-smelling, scanty discharge that is unresponsive to conventional antibiotic therapy. It is often the odor that prompts the patients to seek advice. There is conductive hearing loss that is shown audiometrically. Otomicroscopic examination of the middle ear should be done (18). Specimens should be collected for Gram and acid-fast stains and cultures for aerobic and anaerobic bacteria, mycobacteria and fungi. Biopsy of suspicious tissue should be obtained.

Symptoms And Signs

CMV can be transmitted in utero in both primary and reactivated maternal infections. Gestational age at the time of maternal infection does not seem to affect transmission in utero or expression of disease in the fetus. Infants have a generalized infection at birth, but only 5-10 of them have clinical symptoms at birth. Generalized cytomegalic inclusion disease of the newborn results mostly from primary maternal infection. The most common signs are in decreasing order of frequency petechiae, hepatosplenomegaly, jaundice, microcephaly and chorioretinitis. Multiple organ involvement is frequent. The fetal infection may show minimal manifestations at birth and still result in significant damage in later life, especially to the central nervous system. Infants with subclinical infections at birth may develop sensorineural deafness within the first years of life. Minimal brain dysfunction syndromes have been reported in children with a congenital, subclinical CMV...

Mitochondrial Disorders

More than 50 single nucleotide pair mutations in the mitochondrial genome have been associated with various multisystem disorders. The overall incidence of mitochondrial disorders is about 1 in 10,000 live births. Some of the biological consequences of mitochondrial mutations are myopathy, cardiomyopa-thy, dementia, sudden uncontrolled muscle contractions (myoclonus epilepsy), deafness, blindness, anemia, diabetes, and loss of cerebral blood supply (stroke). The combination of defects associated with a particular mitochondrial disorder depends on a number of factors such as which mitochondrial gene is mutated, the extent of replicative segregation of the mutant mitochondrial genome during the early stages of embryonic development, the abundance of the mutant mitochondrial gene in a particular tissue, and the threshold level of mutant mitochondrial DNA required in a tissue before an abnormality is evident clinically. All of these confounding circumstances make the determination of a...

Mitochondrial Encephalomyopathy with Lactic Acidosis and Strokelike Episodes

The clinical features include recurrent strokes that begin before 40 years of age, myopathy, ataxia, muscle twitching (myoclonus), dementia, and deafness. To a lesser extent, recurring vomiting, migrainelike headaches, diabetes, weakness, or paralysis of the external muscles of the eye that prevents side-to-side movement (progressive external ophthalmoplegia, PEO), droopy eyelids (ptosis), muscle weakness, and short stature are also associated with MELAS. Lactic acidosis is an increase of lactic acid concentration that decreases the pH and lowers the buffering capacity of body fluids. With MELAS, abnormal mitochondria presumably do not metabolize pyruvate and the excess pyruvate is reduced to lactic acid, which accumulates in the blood and other body fluids. A characteristic pathological feature in MELAS patients is the accumulation of large clumps of abnormal mitochondria in the walls of the small arteries and capillaries of the brain and muscles, although it is not clear whether...

Iron Transport Defect

Friedreich ataxia (FRDA) is a fatal trinucleotide repeat expansion disorder inherited as an autosomal recessive trait (see Table 14.3 in Chapter 14 on Molecular Genetics of Neurological Disorders). Clinical features include progressive failure of limb movement and, to a lesser extent, blindness, deafness, and diabetes mellitus. Death before early adulthood is often from hypertrophic cardiomyopathy. Many of these defects resemble the constellation of abnormalities that accompany mitochondrial disorders. Studies of the FRDA gene product, frataxin, in mice and the frataxin homolog in yeast localized this protein to either the inner mitochondrial membrane or the mitochondrial matrix. Biochemical examination of some FRDA patients showed that the uptake of iron-sulfur (Fe-S) clusters that form part of the electron transport function of OXPHOS complexes I, II, and III and aconitase, which is a Krebs cycle enzyme, is not properly regulated when the mutant form of frataxin is present. As a...

The Important Role for Diagnostics A Case Study of Meningitis

A similar dilemma is posed by the treatment of Gram-negative sepsis in older children. A commonly used therapy in the developing world2 is a combination of chloramphenicol and gentamicin (despite the possibility of ototoxicity with gentamicin (Govaerts et al. 1990) and of bone marrow aplasia with chloramphenicol) the alternatives include more effective monotherapy with ciprofloxacin or cefotaxime. Use of more effective antimicrobials would increase per-patient costs for a 15 kg child treated parenterally for 7 days by a factor of nearly 30 or 40, from 2.68 ( 0.38 for gentamicin and 2.30 for chloramphenicol) to 108 or 73 for cefotaxime or ciprofloxacin, respectively (using 2 days parenteral, then oral therapy) (Bejon et al. 2005). Although these figures do not include any estimate of the cost of hearing loss in children, switching to more effective antimicrobials without antibiotic susceptibility testing is unfeasible in most low-income settings.

Facioscapulohumeral Muscular Dystrophy

Facioscapulohumeral muscular dystrophy (FSHD) initially affects the muscles of the face, shoulders, and upper arms, followed by weakening of the pelvic, abdominal, and lower limb muscles. As the loss of facial muscles progresses, some FSHD individuals are unable to close their eyes or smile. Many patients also have hearing loss and abnormalities of the capillaries of the retina. In most cases of FSHD, onset occurs when patients are 20 years of age or older. About

Origin of Altered Proteins

One early explanation of aging was the so-called error-catastrophe theory which posited that an increase in translational errors may cause aging 81 , due to the eventual feedback of errors into DNA replicative enzymes, thereby increasing DNA replication errors and altered (mutant) protein formation. Although the major prediction of this theory, an age-related increase in translational error frequency, has never been realized, it should be pointed out that the theory has not been tested with respect to proteins synthesized by mitochondrial ribosomes 82 . However, it has been shown that decreasing the error frequency of mitochondrial ribosomal protein synthesis increased yeast cell longevity 83 , while increasing the error frequency of cytoplasmic ribosomes in cultured human fibroblasts by paromomycin provoked the onset of cell senescence 84 . Interestingly, the phenomenon of ototoxicity of certain antibiotics has been ascribed to their miscoding effects on mito-chondrial ribosomes...

Diagnostic Procedures

The following procedures are used to test for hearing loss and to diagnose or rule out certain possible underlying causes of hearing loss Audiometry. This is the most commonly used hearing test. The first part measures how well you can hear sounds conducted through the air and indicates the condition of your overall hearing. The test is usually administered in a soundproof room using a machine called an audiometer. Through headphones, you listen to a series of sound tones that range from high to low, one tone at a time. Each tone begins at an easily audible sound level. You indicate with a prearranged signal when you hear the tone. The sound level decreases gradually until you are no longer able to hear the tone this point is your hearing threshold for that frequency. The second part of the test measures how well you can hear sounds conducted through your head and indicates whether your hearing loss is conductive or sensorineural (see page 397). The procedure is the same as for the...

Neurofibromatosis Type

Neurofibromatosis Type 2 (NF2, central neurofibromatosis) is an autosomal dominant trait affecting about 1 in 40,000 people worldwide. The major clinical features are the formation of tumors of the CNS. The most common NF2 tumor is bilateral vestibular schwannoma (acoustic schwannoma, acoustic neuroma), which forms around both acoustic nerves (cranial nerve VIII, vestibulocochlear nerve) in the brain. A schwannoma is a tumor that originates from the sheath cells of neurons. The acoustic nerves emanate from the junction of the pons and medulla oblongata (pontomedullary junction) in both halves of the brain and proceed to each ear. In each of these nerves, one branch (vestibular division) innervates the balance control center of the ear and the other branch (cochlear division) innervates the part of the ear that receives and transmits auditory signals. In NF2 patients, schwannomas often compress each cochlear branch and cause deafness. In addition to bilateral vestibular schwannomas,...

Mitochondrial DNA Defects

A number of kindreds have been found with autosomal dominant inheritance of progressive external ophthalmoplegia (adPEO). In these cases, the pheno-type also includes ptosis, skeletal muscle weakness, sudden death, and, to varying degrees, ataxia, deafness, and depression. Onset of the disorder frequently occurs within the fourth decade of life. Analysis of the mitochondrial DNA of affected individuals from these families indicated that large numbers of mitochondrial genomes have deletions of different lengths. By contrast, individuals with mitochondrion based KSS, PEO, or PS have mitochondrial deletions of equal lengths.

Osteonecrosis Avascular Necrosis or Aseptic Necrosis

Asherson Syndrome

The pathogenesis of sensorineural hearing loss (SNHL) is still considered idiopathic in most cases. Sudden deafness, severe hearing loss of acute onset is usually unilateral, but may also occur bilaterally as well. in antiphospholipid syndrome. Autoimmun Rev 6(6) 409-414 Tektonidou MG, Malagari K, Vlachoyiannopoulos PG, Kelekis DA, Moutsopoulos HM (2003) Asymptomatic avascular necrosis in patients with primary antiphospholipid syndrome in the absence of corticosteroid use a prospective study by magnetic resonance imaging. Arthritis Rheum 48(3) 732-736 Tektonidou MG, Varsou N, Kotoulas G, Antoniou A, Moutsopou-los HM (2006) Cognitive deficits in patients with antiphos-pholipid syndrome association with clinical, laboratory, and brain magnetic resonance imaging findings. Arch Intern Med 166(20) 2278-2284 Toubi E, Ben-David J, Kessel A, Podoshin L, Golan TD (1997) Autoimmune aberration in sudden sensorineural hearing loss association with anti-cardiolipin antibodies. Lupus 6 540-542...

Non Chromosomal Syndromes Associations and Sequences

Famous People With Microcephaly

Infant with the CHARGE association. Occurrence is non-random and is characterized by coloboma, heart disease, atresia of the choanae, retarded postnatal growth and development, genitourinary anomalies, and ear anomalies and deafness. Most infants have some degree of mental deficiency. The coloboma commonly involves the retina but may range in severity from an isolated coloboma of the iris to anophthalmos. Figure 3.10. Infant with the CHARGE association. Occurrence is non-random and is characterized by coloboma, heart disease, atresia of the choanae, retarded postnatal growth and development, genitourinary anomalies, and ear anomalies and deafness. Most infants have some degree of mental deficiency. The coloboma commonly involves the retina but may range in severity from an isolated coloboma of the iris to anophthalmos.

Perinatal Infection

Cocci Lesions

The immediate and long-term effects of perinatal infection are a major problem throughout the world. Perinatal infection is relatively common among the over 4 million births per year in the United States but the incidence is dependent upon the organism. One percent of newborn infants excrete cytomegalovirus. Fifteen percent are infected with Chlamydia trachomatis one-third develop conjunctivitis and one-sixth, pneumonia. One to eight per 1,000 live births develop bacterial sepsis. In utero or perinatal infection with herpes simplex virus, Toxoplasma gondii and varicella-zoster virus occurs in about 1 per 1,000 live births and the sequelae may be severe. In-utero acquired infection may result in resorption of the embryo, abortion, stillbirth, malformation, intrauterine growth retardation, prematurity, and the numerous untoward sequelae associated with chronic infection. Infection acquired at or soon after birth may lead to death or persistent postnatal infection. Some infections may be...

Didronel etidronate is usually prescribed for Pagets disease Is it ever prescribed for osteoporosis

Although Paget's disease is also a bone disease, it is totally unrelated to osteoporosis. One person can have both conditions. Paget's disease causes large, deformed bones because of an excessive breakdown and formation of bone. The most common presenting symptom is bone pain located where the bone is closest to a joint. Paget's disease can often be mistaken for arthritis because it is usually diagnosed in people who are over 40 years of age. However, x-rays of bones in individuals with Paget's disease show a characteristic pattern and fractures occur frequently. Blood levels of alkaline phosphatase are usually elevated in people with Paget's disease. If the skull bone is affected, hearing loss can result.

Review the alleged benefits and risks of ginkgo

Ginkgo is used for the treatment of dementia, Alzheimer's disease, and conditions associated with cerebral vascular insufficiency, including memory loss, headache, tinnitus, vertigo, difficulty concentrating, mood disturbances, and hearing disorders. Active ingredients of ginkgo leaf and its extracts include flavonoids, terpenoids, and organic acids. Although the mechanism of action is only partially understood, there are several theories about how ginkgo works. Ginkgo may protect tissues from oxidative damage by preventing or reducing cell membrane lipid peroxidation and decreasing oxidative damage to erythrocytes, and it may protect neurons and retinal tissue from oxidative stress. Extracts from the ginkgo leaf competitively inhibit platelet-activating factor, decreasing platelet aggregation, phagocyte chemotaxis, smooth muscle contraction, and free radical production, and prevent neutrophil degranulation. A case of bilateral spontaneous subdural hematomas has been linked to chronic...

Myoclonus Epilepsy and Ragged Red Fibers

Myclonus epilepsy and ragged red fibers (MERRF) is a rare, maternally inherited, heteroplasmic, debilitating multisystem disorder that includes transient seizures (myoclonus epilepsy), failure to coordinate muscle movement (ataxia), loss of muscle cells (myopathy), and, to a lesser extent, dementia, deafness, and degeneration of spinal nerves. The term ragged red fibers refers to large clumps of abnormal mitochondria that accumulate mostly in muscle cells and are stained red by a dye that is specific for complex II of the electron transport chain. In general terms, MERRF is a member of a group of disorders called mitochondrial encephalomyopathies that feature mitochondrial defects with altered brain and muscle functions. In patients with severe forms of MERRF, neuronal loss occurs in the olivary and dentate nuclei of the brain and in regions of the cerebellum, brain stem, and spinal cord. Onset of MERRF is usually during childhood, with the condition often persisting for many years.

Adenosine Deaminase Narcolepsy Ear Infections

The primary targets of newborn screening programs are monogenic disorders. However, as the detection systems become more sophisticated, genetically heterogeneous and complex (multigenic) conditions may become candidates for newborn testing. For example, deafness hearing loss occurs in 1 in 500 births in the US. And, because at least 60 different genes contribute directly or indirectly to this phenotype, it is difficult to pinpoint the basis of sporadic and familial hearing loss. Regardless of whether deafness has either a genetic or nongenetic origin, detection before 6 mo of age that is followed with the appropriate training leads to normal speech development and academic achievement. Moreover, the need for expensive rehabilitation programs during school years is minimized. Electrophysiological procedures that are painless and noninvasive and require about 5 min to perform determine the extent of hearing in infants. One of these tests entails placing electrodes on the head of a...

Haemorrhagic Fever Viruses

Common clinical features are fever, headache, haemorrhages in the skin and mucous membranes. Case fatality rate is particularly high in secondary attacks of dengue, apparently due to immunological mechanisms. Deafness, hair loss and psychomotor disturbances are frequently recorded sequelae in Omsk haemorrhagic fever.

Rhinitis Associated With Systemic Diseases or Anatomical Defects

Wegener's granulomoatosis may present initially with upper airway complaints, particularly hearing loss, intractable sinusitis, and persistent nasal congestion associated with purulent or bloody nasal discharge. Sarcoidosis of the nasal airway may appear similarly, although not usually as necrotizing. Persistent sinusitis or recurring infectious complications should prompt consideration of cystic fibrosis, partially cleft or submucosal cleft palate, humoral immunodeficiency, or ciliary dysfunction. Table 7 lists potentially useful tests to discriminate among the systemic possibilities.


More specifically, BDNF has been localized to sensory cells of both auditory and vestibular organs, while NT-3 is expressed in inner hair cells and to a lesser extent in outer hair cells (75). Receptors for these neurotrophins have been localized to SGNs (75,76). SGNs are classified as type I or type II based on their specific functions. Type I SGNs deliver sound signal information from the inner hair cells to the brain, while type II SGNs innervate outer hair cells (77). Both type I and type II SGNs require neurotrophin-3 (NT-3) for survival. Severing the cochleovestibular nerve, aminoglycoside ototoxicity of the hair cells and cisplatin administration all lead to a secondary degeneration of the spiral ganglion neurons (6,68,70,78). In turn, destruction of hair cells and SGN degeneration result in hearing loss. Some forms of deafness are alleviated by cochlear implants, which are surgically implanted hearing aids that are placed directly in the scala...

Diagnostic Tests

In children older than 18 mo, audiometry is an important test in determining whether OME has resulted in hearing loss. Fluid may cause up to a 40 dB hearing loss. This test should be employed when middle ear fluid has been present for at least 3 mo before deciding whether ventilation of the middle ear is necessary.

Surgical Therapy

Myringotomy with tube placement is effective in reducing the frequency of acute infections and in decreasing the duration of chronic effusions and their associated hearing loss. If tube placements are not effective or a child has persistent adenoidal infection or enlargement, adenoidectomy with repeat tube placements has been shown to be beneficial in children older than age 4. Tonsillectomy has not been shown to provide any additional benefit over adenoidectomy alone.

Kearns Sayre Syndrome

The common clinical features of Kearns-Sayre syndrome (KSS) are progressive external ophthalmoplegia (PEO) and degeneration of the pigment layer of the retina. Often the KSS phenotype includes cardiac conduction abnormalities, ataxia, and, to a lesser extent, deafness, dementia, and diabetes melli-tus. Onset begins before 20 years of age, and most patients die a few years after diagnosis.

Adverse effects

Most side-effects are gastrointestinal. Erythromycin in particular can cause nausea and vomiting in some patients. Clarithromycin and azithromycin are tolerated better, and are good alternatives in patients who are intolerant of erythromycin. Some patients are allergic to macrolides, and a hypersensitivity to one macrolide confers cross-class allergy. Erythromycin has also been known to cause reversible hearing loss. Erythromycin is safe to use in pregnancy and lactation. Azithromycin is not licensed in the UK for use in pregnancy however, some GUM centres use it in pregnancy following a detailed discussion with the mother-to-be.

Platelet Pathology

This is another condition in which cytoplasmic inclusions are noticeable in platelets on Wright-Giemsa stained peripheral blood smears. Fechtner syndrome is also characterized by renal disease (nephritis) and deafness (53). The cyto-plasmic inclusions appear smaller and pale blue in contrast to those seen in the May-Hegglin anomaly. Large platelets are seen in Fechtner syndrome, with thrombocytopenia in the range of 30-90 x 103 L (30-90 x 109 L) (21). Ultrastructural changes are seen in megakaryocytes characterized by abnormal accumulation of demarcation membranes, leading to ineffective platelet production and resulting thrombocytopenia (54).


Tinnitus is caused by hearing loss or by spasms (involuntary muscle contractions) in the muscles of the neck or jaw. The hearing loss, which may not be noticeable, may result from a variety of diseases and conditions, including stiffening of the bones in the middle ear, allergies, high blood pressure, diabetes, a tumor, a thyroid condition, or head or neck injury. Certain medications such as anti-inflammatory drugs, antidepressants, aspirin, or antibiotics can trigger tinnitus. However, most cases of tinnitus result from damage to the sensory hair cells and the microscopic endings of the auditory nerve, which are in the inner ear. This damage is common in older people. In younger people the damage usually results from continual exposure to loud noise. Hearing loss typically accompanies tinnitus, but one often becomes apparent before the other.

Terminase Inhibitors

HCMV is widespread in the human population. In immunocompetent individuals, the infection is inapparent or associated with mild symptoms. However, HCMV is frequently transmitted perinatally and is the leading cause of neurological disease and hearing loss in congenitally infected newborns, affecting some 8,000 newborns per year in USA alone (Arvin and Alford 1990). Furthermore, following the first 100 days after transplantation, HCMV-induced pneumonia develops in about 50