Therapy And Prophylaxis

Antigenic epitopes on the E6/E7 proteins of high-risk HPVs, and their interaction with CMI effector functions, are being extensively studied. The ultimate goal, a protective vaccine, does not seem to be within short-term reach.

Most skin warts regress spontaneously. Various local treatments have been attempted with uncertain effect (podophyllin, salicylic acid, glutaraldehyde, acetic acid and freezing). When the wart is troublesome, surgical removal may be necessary. Interferon has been used for treatment of laryngeal papillomas with favourable results. In approximately 50% of refractory cases, however, relapse is common. Education concerning prevention of sexually transmitted diseases should include appropriate counselling about HPV infections.

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