References

Pharmacokinetic pharmacodynamic parameters rationale for antibacterial dosing of mice and men. Clin Infect Dis 1998 26 1-12. 2. Vogelman B, Gudmundsson S, Leggett J, Turnidge J, Ebert S, Craig WA. Correlation of antimicrobial pharmacokinetic parameters with therapeutic efficacy in an animal model. J Infect Dis. 1988 158 831-847. 3. Vogelman B, Gudmundsson S, Turnidge J, Leggett J, Craig WA. In vivo postantibiotic effect in a thigh infection in neutropenic mice. J Infect Dis 1988 157...

Catheter Associated Urinary Tract Infections

Urinary tract infections account for about 40 of all hospital-acquired infections (47). Instrumentation, particularly indwelling catheterization, is responsible for the majority of nosocomial UTIs (48). Therefore, using these catheters only when indicated, inserting and maintaining them properly, and removing them when they are no longer needed are important. Urinary catheters are overused in many hospitals and are left in for longer than needed catheters should never be used for convenience...

The Targeted Approach To Antibiotic Utilization

Hospital Acquired Infection Diagram

Ideally, clinicians should prescribe antimicrobial therapy with the goals of providing appropriate initial therapy to hospitalized patients with serious infections and minimizing the emergence of bacterial resistance. Various strategies for the prevention of antibiotic resistance have been proposed in terms of improving overall antibiotic utilization (32,33). Table 1 highlights several of these strategies aimed at either limiting the unnecessary use of antibiotics or optimizing their...

Campaign To Prevent Antimicrobial Resistance In Health Care Settings

In health care settings, where infection with multidrug-resistant organisms is a major patient safety issue, promoting appropriate antimicrobial drug prescribing is complicated by the higher stakes involved in treating sicker patients and the need to develop partnerships with a greater number of medical and surgical specialties involved in their care, as well as with other clinical staff and administrators. The CDC's Campaign to Prevent Antimicrobial Resistance in Healthcare Settings aims to...