Box 33 Immune Modulators and Fungal Infections

The immune system is powerful, and sometimes it goes astray. For example, rheumatoid arthritis, a painful swelling of joints, involves the excessive action of tumor necrosis factor-a an important protein component of the immune system. Anti-inflammatory agents, such as corticosteroids, relieve the symptoms of arthritis. But they also weaken the defense against fungi. Because the current medicines never actually cure arthritis, they must be taken for life. That makes fungal infection a constant threat.

mRNA, it prevents synthesis of proteins by fungal ribosomes. In addition, enzymes in fungal cells chemically modify flucytosine, causing the drug to inhibit another enzyme (thymidylate synthetase) that is essential for DNA synthesis. Unfortunately, resistance emerges readily. Consequently, flucytosine has limited utility.

Fungal infections range from being a nuisance to being life threatening. A variety of skin infections, such as ringworm, athlete's foot, and jock itch are caused by fungi. Skin infections are often controlled by topical creams containing tolnaftate, an inhibitor of ergosterol synthesis. Tolnaftate and related compounds are generally ineffective against fungal infections that grow under the nails of toes and fingers, because nails serve as tough barriers to drug entry. However, nail infections can be treated with another compound, griseofulvin, which is administered systemically. Many months of treatment are required to permit the nails to grow out fungus-free. Among the side effects of griseofulvin treatment are liver problems; consequently, liver function is usually monitored during treatment.

Arthritis Relief Now

Arthritis Relief Now

When you hear the word arthritis, images of painful hands and joints comes into play. Few people fully understand arthritis and this guide is dedicated to anyone suffering with this chronic condition and wants relief now.

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